TLRs

Question 1

CLRs

Answer 1

C-type lectin Receptors

Question 2

Where are CLRs

Answer 2

transmembrane proteins on plasma cells

Question 3

CLRs recognise

Answer 3

Glycans- from wall of fungi and some bacteria

Question 4

CLR activates

Answer 4

syk, CARD9/MALT1/ Bcl-10 adapter complex

Question 5

example of CLRs

Answer 5

Dectin-1 recognise Beta 1 glucans on the cell wall of fungi

Question 6

NLR

Answer 6

Nod-like Receptors

Question 7

NLR subfamilies

Answer 7

NLPRs, AIM2, NOD1 and NOD2

Question 8

Where are NLRs

Answer 8

Cytoplasm

Question 9

What do NLRs recognise

Answer 9

Bacteria, viral, parasitic and fungal PAMPs

Question 10

AIM2 detects

Answer 10

Viral and bacterial DNA

Question 11

wHAT DOES aim2 FORM

Answer 11

MULTIPROTEIN SIGNALLING COMPLEXES (INFLAMMASOMES)

Question 12

General function of inflammasome

Answer 12

Activates caspase-1-mediated processing and IL-1B, IL-18

Question 13

What do NOD1 and NOD2 recognise

Answer 13

bacterial peptidoglycan

Question 14

TLRs

Answer 14

Toll-like receptors

Question 15

where are TLRs

Answer 15

transmembrane proteins at plasma membrane or endosomes

Question 16

TLR recognise

Answer 16

Proteins, nucleic acids, glycans

Question 17

TLRs activate

Answer 17

MAP kinase, NFkB and IRF pathways

Question 18

example of TLR

Answer 18

TLR4 recognises LPS, component of gram negative bacteria wall

Question 19

LPS

Answer 19

Lipopolysaccharides

Question 20

RLR

Answer 20

RIG-like receptors

Question 21

Where are RIGs

Answer 21

cytoplasmic sensors of viral RNA

Question 22

RIG signal

Answer 22

via Mitochondrial adapter protein (MAVs)

Question 23

RIG

Answer 23

trigger antiviral responses including production of type 1 interferon

Question 24

TLR3, 7/8 and 9

Answer 24

9 recognise viral RNA or DNA to induce the expression of type I interferon

Question 25

Viral genomes

Answer 25

ssRNA, DNA, dsRNA

Question 26

what is unique about the structural components of viruses

Answer 26

varied and highly mutated