Tissus squelettiques Flashcards

1
Q

chez adulte, zone insertion des tendons quelle nature

A

lamellaire (mature)

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2
Q

origine osteoclastes

A

lignee hematopoetique mono/macro

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3
Q

partie ext os court ou long quelle nature ?

A

os compact

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4
Q

pq tissus trabeculaire

A

os spongoeux ac lamelles en reseau de travees anastamosees

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5
Q

osteoclastes cb de noyau

A

30-40

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6
Q

role cartilage de conjugaison

A

croissance ne L des os longs

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7
Q

def osteone

A

unite de base du tissu lamellaire COMPACT (petit cylindre de lamelles osseuses compact)

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8
Q

def sys circonfrentiel ext

A

ensemble des lamelles osseuses circ en periph, au conact du peioste

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9
Q

phase organique compte pour 70% MEC osseuse

A

non phase minerale

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10
Q

fibrilles de CII visibles en MET

A

invisible en MO

visibles en MET !!

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11
Q

ct mineralisation MEC

A

precipiatation Ca2 + et phosphate grace aux phosphatases alcalines

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12
Q

quelles fibresnon fibrillaires ds cart

A

VI etIX

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13
Q

% eeau ds MEC cart

A

80%

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14
Q

role des proteoglycane

A

resistance a la compression

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15
Q

ou ds nez cart elastique

A

aile du nez

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16
Q

ou cart hyalin

A

voies aeriennes, os coaux

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17
Q

PG ds cart hyalin

A

OUI

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18
Q

ct fibres cart hyalin

A

oriente

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19
Q

cart articulaire fibres ct

A

//

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20
Q

eg os plats

A

crane cotes sterneum

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21
Q

methodes de os et densite

A

osteodensitometrie

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22
Q

cart arti fixes

A

zone de contact : os, cart fibreux ou TCD

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23
Q

cart arti mobiles

A

cavite arti + zone de contatc (cart hyalin)

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24
Q

os secondaire ct

A

lamellaire + resis

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25
Q

roles de os

A

Ca - phsophate - AB -

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26
Q

ou hematopoiese

A

ds logettes

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27
Q

quelles cell ds endoste

A

cell osteoprogenitrices –> hematopoiese

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28
Q

2 couches du periostse (+ gaine conjonc fibroblaste autour)

A

ext fibreuse et int osteogenique

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29
Q

quels cristaux os

A

hydroxyapatite

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30
Q

prot non colla de mec osseuse

A

PG - Osteopontine - Osteonectine - Sialoprot - Thromboondine

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31
Q

marqueur de synthese osseuse et act osteoblastes

A

act des phosphatases alcalines

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32
Q

etapes de mineralisation

A
  1. formation TO 2. Front de mineralistion 3. Phosp alcaline 4.Mineralisation
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33
Q

fixation des osteoclastes sur matiere osseuse

A

fixation des ventouses qui ont des integrives v321 qui reconnaisant RGD + ?

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34
Q

origine des osteoclastes

A

fusion de noyaux de pre osteoclastes

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35
Q

osteoblastes : ont de sgranules

A

oui ca

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36
Q

lacune de Howship

A

ATP Cl et H+ et cree par des osteoclates

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37
Q

what happens in lacaune

A

dissoc des cristaux car ph=2-3 et phosphatases happy

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38
Q

lacune de howship a de nbses pompes aprotons

A

oui

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39
Q

ossi endo : chondrocytes sécrètent quoi

A

de la phosph alcaline comme les ostéoblastes dans la phase de formation du tissu osseux, lors du remodelage osseux.

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40
Q

fracture : netoyage puis formation os reticulaire puis primaire

A

non d’abord TC puis cart

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41
Q

qui stimule formation MEC non mineralisee par les osteoclastes

A

oestro et androgenes

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42
Q

cell osteoformatrices

A

blastes -cytes - bordantes

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43
Q

impact absence de RANK

A

osteopetrose

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44
Q

couche tendiforme cart

A

couche ext donc SUPERFICIELLE

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45
Q

chondrocytes : % du volume du cart

A

1-10%

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46
Q

chondrocytes peuvent se diviser au sein des chondrolastes

A

oui –> augmentation de la taille des pieces car

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47
Q

ou cart elastique

A

conduit auditif EXT - trompes - pavillon des oreilles = oreille EXT - ailes nu new - epiglotte

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48
Q

def perichondre

A

TC periph (nerfs capillaires)

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49
Q

croissance en epaisseur du cart

A

chondrogene : fibrobalstes –> chndrobalstes qui synth CII

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50
Q

couche ext fibreuse du perichondre

A

synon = tendiforme

TC dense fibres ancrage arci CI

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51
Q

croissance du cart : quelle cell

A

chondrocytes (in chondroplastes)

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52
Q

cart articulaire : orientation des fibres

A

paralleles

53
Q

nutrition du cart arti

A

liqueide syno de mem synovial de la face INT de la capsule

54
Q

TO permeable

A

imperable car calcifie

55
Q

pq radiogrpahie

A

MEC calci –> noir et os en blc

56
Q

classification histo des os

A

criteres ana, macro, micro, mode de formation

57
Q

ou multiplication et diff des cell sanguines

A

logetes osseuses

58
Q

quelles cell sont a action antagoniste

A

tissu osseux

59
Q

cell du TO m origine

A

non

60
Q

cytoplasme des cell bordantes

A

pauvre en organites car inactif

actif = osteoblastes

61
Q

descri des osteoblates

A

cube - gros noyau ovale - granule - ccyto basophile

62
Q

osteoblastes communiquente avec qui

A

o.cytes : ac canalicules

autres o.blastes : jonction GAP

63
Q

qui permet formation d’une veritable unite fonctionnelle

A

prolongement cytoplasmiques

64
Q

def osteoide

A

phase orga de MEC

65
Q

fonciton osteoblastes

A

synthe CII de osteoide de maniere SYNCHRONE

66
Q

3 possi de devenir des psteoblastes

A

quiescentes (bordantes) - apoptose - osteocytes

67
Q

osteocyttes et division

A

impossible

68
Q

mnemonic steocyres

A

gaurdien vieille (peu active)

69
Q

qui SEUL peut resorber une MEC mineralisee

A

osteoclastes

70
Q

fixation des osteoclaste

A

osteoclates reconnaisent RGD (argiglyaspar) de la MEC –> expre integrines specialesv321 sur leurs podosomes

71
Q

osteoclastes emet microvillosites ?

A

oui ds la lacune de howship –> bordure en brosse augmente la surface

72
Q

taille de la lacnue

A

40microns rose

73
Q

acidification de la chambre

A

pompe a pronts ATP - CO trasnsport de chlore

74
Q

2 consequences de acidification de la chambre

A
  1. org : lysosome secrete +++ enzymes proteolyitqie

2. mine : HCl dissous

75
Q

eg enzymes protelolyqies

A

collagenases, metallopreoteinases, phosphatases acides, cathepsines

76
Q

MEC osseuse quelles prop

A

mecanique

77
Q

qui synthetise MEC

A

osteoblastes

78
Q

mineralisation de la MEC osseuse

A

a distance : entre les fibres de CI, apparition de cristaux

79
Q

% eau MEC osseuse

A

50%

80
Q

mineralisation de la MEC

A

o.blastes-> phosphatases alcalines –> precipiation concentration saturantes Ca2+ , Phos

81
Q

origine du calcium de la MEC osseuse

A

osteoblastes :vesicule matrieilles des

82
Q

ou se passe precipataion

A

bordure osteoide

83
Q

prots non colage

A

PG, o.pontine (fixation des osteoclastes

0, o.nectine (croissance des cristaux) - sialo prot (++), thrombospondine (+++ - l g integrines)

84
Q

role o.calcine

A

++++++ - dosage plasma possible (marqueur osteoformation) - en cas de resopb: stimule les osteoclastes

85
Q

dimemsions hydroxyapatite

A

50-30-3 Nm

86
Q

2 phases MEC minerale

A
  1. surface : eau + ions => dure - role MAJEUR meta phosphocal - carbonate de potassium
  2. couche int : plus stable
87
Q

perioste partout ?

A

suafinsertion des ligaments - cart artic

88
Q

perioste et perichondre ?

A

// (perioste : fibres de sharpey = traverse couche interne pour s’ancrer TO)

89
Q

perioste couche inter

A

cell mesencyy –> diff en osteoblastes => croissance EPAISSEUR

90
Q

ou sont les osteoprogenitries

A

endoste

91
Q

ou se trouve os reticulaire (non lamellaire - non TISSE) chez adulte

A

zone insertion des GROS tendons

92
Q

MEC os non tisse tres mineralisee ?

A

peu => donc moins resis

93
Q

os : composee de lamelles osseuses ct

A

superposees

94
Q

fibres de collagene os reti

A

peu abondantes- entrecroisees en FAISCEAUX sans ordre app

95
Q

ou sont les osteocytes

A

entre 2 lamelles contigues

96
Q

os lamellaire : fibres de C

A

C1 - paralleles - direction diff de 90 degres dune lamelle a luatre => orientation diff multidrectionnelle d’une lamelle a l’autre

97
Q

2 types de lamelles (EN ALTERNANCE)

A

cimentantes - fibriallire (fine - peu mine)

98
Q

quel eg os tres solicite

A

col du femur

99
Q

resistance os spongieux vs lamellaire

A

= (grace a dispositon des travees osseuses)

100
Q

def logettes osseuses os trabeculaire

A

esp libre du reseau 3d des travees osseuses et recouvert d’endoste

101
Q

quels eg de os a moelle osseuse hematoi

A

sternum - os iliaque

102
Q

def osteone

A

petit cylindre de lamelle osseuse concentrique

103
Q

dimension osteone

A

L : pls cm

d : 1mm

104
Q

taille canal de havers

A

PETIT d: 80microns (comme la lacune)

105
Q

interieur du canal de Havers

A

endoste (=TC lache)- lymphe - capi - fibre nereuse Amyelinique

106
Q

diff canal V vs H et similiarite

A

transversal vs longitudinal

renferme endoste

107
Q

sys intermediaires/intersititiel

A

entre lamelles , systeme de Haver spartiellement resorbe

108
Q

ou abouche canaux de Volkman

A

lamelles circon INT

109
Q

sys cirocon EXT en continiute avec qui

A

perioste

110
Q

ossificaiotn primaire vs secondaire

A

de novo vs resobrtion

111
Q

squelette prexistant embryon

A

squelette mesenchymateux

112
Q

ossifi primaire au niveau de endoste possible

A

oui

113
Q

croissance en epaiseeur des os

A

ossi periosteique = intraconjonctive de membrane

114
Q

ossi endochondrale quels types os

A

croissance en LON des os longs ou qd FRACTURE

115
Q

ossi primaire diaphyse s’etend axial ou radial

A

axial

116
Q

ossification primaire logique

A
  1. O.blastes –> TC / osteoprogrnitice du sf

2. MEC calcifiee (pas de cloisons (g chondroclastes) - vascularisee

117
Q

ossification primaire preocessus INTEGRALITE

A
  1. pt ossi primaire
  2. pt ossi epiphyse
  3. os primaire (reticulaire) –> secondaire
118
Q

puberte x croissance des os

A

h. sex –> plus de multipica chondrocytes –> plus de cart serie –> plus de cart d ecroissace

119
Q

quelles hormones entrainent diminution de la masse osseuse

A

PTH et cortison –> stimulent M CSF et inheosteoprote dc + o.clastes recutre (RANK L) aug,em vs oestro : active formation du tissu

120
Q

docteur fracture

A

reduction : aligment

maintien : broche platre fixateurs ext

121
Q

fracture : que passa inside

A

destruc tissu + hemorragie => granu enutro et macrphaes

122
Q

hormones stimulant osteoblastes et leur secretion du MCSF

A

D, PgE2, PTH, (et o.cytes)

123
Q

hormones stoppant action des o.clastes

A

calcitonine et osteoblast secrete ODF qui se lie sur recept RANK donc plus de RANK donc plus d’activation de o.clastes posible

124
Q

hormones stimulent formation TO

A

oestro/andro

vitamin D fac de croissance BMF

125
Q

que passa si insuffisance renale

A
  1. acidose metabolique stimule trop de resorbtion
  2. impossi d’hydroxyler vitamin D
    ==> troubles phsopcall
126
Q

vitamin D qd

A
  • stimulation des osteoblastes : MCSF

- formation des osteblastes

127
Q

cart hyalin possede du C1

A

NON que C2 - c;est Cart fibreux qui a C1 et C2

128
Q

osteone ds os spongieux

A

non : osteone = os compact

travees = os spongieux

129
Q

invalidation du gene OPG entraine osteoperose

A

non osteoPOROSE