Tissue response to Biomaterial implant

Question 1

What is the cellular response to digestible wear debris?

Answer 1

phagocytosis 
1) Ligand coating of particle
2) Ingestion by phagocyte 
3) Formation of phagosomes 
4) Fusion of phagosome with a lysosome to form phagolysosome 
5) Digestion by enzyme
6) Discharge of waste material 
inflammatory stimuli release stopped

Question 2

What is the cellular response to indigestible wear debris?

Answer 2

phagocytosis

1) Ligand coating of particle
2) Ingestion by phagocyte
3) Formation of phagosomes
4) Fusion of phagosome with a lysosome to form phagolysosome
5) Frustrated digestion by enzymes
6) Permanent residual body
7) Perpetual inflammation

Question 3

3 factors causing conformational changes in proteins

Answer 3

• surface absorption
• complexation of released metal cations as a result of corrosion
• alteration of fluid flow and increased shear forces

Question 4

Define bioresorbable

Answer 4

a material designed to degrade within the body after performing its function

Question 5

what determines tissue response to implants?

Answer 5

- biomaterial properties 
inert or bioactive?
resorbable or non-resorbable
toxicity
physical attributes eg size 
- host biological properties 
site of implant 
immunological condition of patient