Tissue Healing Flashcards
1
Q
Acute timeline
A
7-10 days
2
Q
Subacute timeline
A
5-10 days after acute
3
Q
Chronic timeline
A
Injury lasting longer than expected under “normal” healing conditions
4
Q
Ligament Phase I
A
- Acute inflammatory response and hematoma formation
- Days 1-3
5
Q
Ligament Phase II
A
- Fibroblasts produce collagen
- Matrix disorganized
- 2-3 days post injury to 6 weeks
6
Q
Ligament Phase III
A
- Collagen fibers become more parallel/organized
- Increased tissue contraction and tensile strength
- 12 months post injury
7
Q
Tendon Phase I
A
Inflammatory
1st 3 days
8
Q
Tendon Phase II
A
- Begins within 1st week
- Increased fibroblastic activity through week 4
- Collagen fibers initially formed disorganized and at random
- Cells and collagen become more aligned more perpendicular to long axis over time
9
Q
Tendon Phase III
A
- Collagen / cells re-alignment typically complete by 2 months
- After initial healing CONTROLLED tensile loading
10
Q
Articular cartilage:
Chondral
A
Limited response per no inflammatory response
11
Q
Articular cartilage: Subchondral
A
- Extends to blood supply
- Fills in with tissue more like fibrocartilage
- Fibrin clot at 48 hrs
- 2 months resembles “normal” cartilage
- erosive changes observed around 6 months
12
Q
Articular cartilage: Subchondral
When does cartilage resemble “normal” cartilage?
A
2 months
13
Q
Articular cartilage: Subchondral
When are erosive changes observed?
A
6 months
14
Q
Articular cartilage: Subchondral
When do you see a fibrin clot?
A
48 hrs
15
Q
Articular cartilage: Subchondral
What type of cartilage fills in initially?
A
fibrocartilage
