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tissue engineering Flashcards

1
Q

what are the advantages and disadv of CaOH pulp capping?

A
  1. excellent antibacterial properties
    2) induces min of dentin
  2. low cytotoxicity

disadv:

  1. high soluble in oral fluids
  2. subject to dissolution
  3. presence of funnels in reparative dentin
  4. lack of adhesion
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2
Q

what are the adv and disadv of ZOE as a pulp cap?

A

adv:
1. reduces inflammation

disadv:

  1. lack of calcfic bridge formation
  2. release eugenol inhigh conc–>cytotoxicity
  3. interfacial leakage
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3
Q

what are the adv and disadv of corticosteroids and abx for pulp capping?

A

adv:
1. reduces pulp inflammation
2. vancomycin and CaOH stimulate more reparitive dentin

disadv:
1. should not be used in pts with risk from bacterimia

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4
Q

what are the adv and disadv of polycarboxylate cements as pulp capping material?

A

adv:
1. chem. bonds to tooth

disadv:

  1. lacks antibacterial effects
  2. does not stimulate calcific bridge formation
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5
Q

what are the adv and disadv of inert materials like ISOBUTYL CYANOACRYLATE and CaPO3

A

adv:
1. reduces pulp inflammation
2. stims dentin bridge formation

disadv:
1. not viable bc of lack of technique

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6
Q

what are the adv and disadv of collagen as a pulp cap mateiral?

A

adv:
1. less irritating, promotes mineralizatiopn

disadv:
1. does not help in thick dentin bridge formation

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7
Q

describe calcium phosphate as a pulp cap material

A

adv:

  1. helps in bridge formation with no superficial necrosis
  2. no inflammation
  3. good physical properties

disadv:
1. must perform clinical trials to evaluate this mateiral

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8
Q

what are the adv and disadv of hydroxyapatite as a pulp capmaterial?

A

adv:

  1. biocompatible
  2. scaffold for new dentin formation

disadv:
1. mild inflammation with superficial necrosis of pulp

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9
Q

what are the adv and disadv of CO2 lasers

A

adv

  1. formation of secondary dentin
  2. bacterialcidal effects

disadv

  1. technique sensitive
  2. cause thermal damage to pulp at high doses
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10
Q

what are the adv and disadv of GI/RMGI as a pulp cap material?

A

adv

  1. excellent bacterial seal
  2. fluoride release,
  3. CTE and modulus of elasticity similar to dentin
  4. good biocompatibility

disadv

  1. causes chronic inflammation
  2. lack of dentin bridge formation
  3. cytotoxic when in direct cell contact
  4. high solubility and slow setting rate
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11
Q

what are the adv and disadv of MTAas a pulp capping material

A

adv

  1. good biocompatiblity
  2. not much pulpal inflammation
  3. more predictable hard tissue barrier
  4. radiopacity

disadv

  1. expensive
  2. poor handling characteristics
  3. two step procedure
  4. high solubility
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12
Q

what are the adv and disadv of growth factor as a pulp capping material?

A

adv

  1. formation of osteodentin and tubular dentin
  2. formation of more homogenous reparative dentin
  3. superior to CaOH for mineralization

disadv

  1. high conc required
  2. half life is less
  3. appropriate dose response is required to prevent obliteration of pulp chamber
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13
Q

what are the adv and disadv of odontogenic meloblast associated proteins

A

adv

  1. biocomaptible
  2. accelerates reactionary dentin formation
  3. does not promote excessive teriary dentin formation

disadv:
1. only in vitro studies conducted
\2. further studies required

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14
Q

what are the adv and disadv of thera cal as a pulp capping material?

A

adv

  1. protect pulp
  2. strong physical properties
  3. no solubility
  4. radiopaque
  5. good Ca release

disadv
1. can affect composite shading–unesthettic

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15
Q

what ar ethe factors that determine the success ofpulp capping?

A
  • remaining dentin thickness

- choice of indirect pulp capping agent

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16
Q

what is the purpose of cyanoacrylate

A
  • placed over wound site
  • polymerizes in the presence of moisture
  • forms a PROTECTIVE COATING
17
Q

what are the adv and disadv of cyanoacrylate monomer?

A

adv

  • good biocompatilbity (only butyl and isobutyl forms)
  • good tissue adherence
  • biodegradable–>wound heals and it breaks down
  • provides hemostasis
  • bacteriostatic
  • easy to apply (to small surfaces)
  • shortens operation time

disadv:

  • difficult to apply to large wounds
  • is toxic in methyl form
18
Q

what is n-butyl-2-cyanoacrylate and what is it used for?

A

a tissue adhesives, not cytotoxic –> can be used instread of stitches and parrier from food/debris during the healing period

19
Q

what are the absorbable sutures?

A

PGA
PDO
catgut

20
Q

what are the non-absorbable sutures?

A

silk
polyester
nylon

21
Q

what is an important benefit of an alloplast?

A

do not pose the risk of transmitting disease

22
Q

what is guided tissue regeneration?

A

undesired cells excluded from repopulating a defects or injury site by placing a physical barrier; desriable cells can enter

23
Q

describe cell induction as tissue regeneration?

A

growth and differentiation factors are injected; can also create gene vectors and cause growth/diff factors to be produced endogenously

24
Q

describe cells as a scaffolding matrix as a strategy for tissue engineering

A

preformed scaffolds are seeded with cells from a pt; grown in vitro –> increase in # of cells–> start producing matrix; with enough growth, implanted back into pt, cells grow and develop into tissues; scaffold resorbs and leaves no former prescence

25
Q

strategries for tx engineering?

A
  1. injection of cells – right at site of injury
  2. guided tissue regeneration
  3. cell induction –
  4. cells in a scaffold matrix
26
Q

what does SIBLINGs stand for

A

small integrin bindin ligand, N-linked glycoprotein

  • includes bone sialoprotein (BSP),
  • osteopontin (OPN)
  • dentin sialophosphoprotein (DSPP)
  • dentin-matrix protein 1 (DMP-1)
  • matrix extrecellular pohosphoprotein (MEPE)
  • noncollagenous
  • mediate cell adhesion
27
Q

what does allotropic mean?

A

that an element can exist in different physical forms

28
Q

what materials are used in perio, and for what purpose?

A

used to promote healing

  • ZOE
  • Non-eugenol (zinc polyacrylate, resin)

cyanoacrylate molecule

DM (18 decks)

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