TI

Question 1

Tumor cells can ________ expression of MHC class 1 to evade __________ attack

Answer 1

Lose

Cytotoxic T cell

Question 2

NK activation receptor ______________ mediates _____________

Answer 2

FcgammaR

ADCC

Question 3

NK cells produce __________________ which can activate macrophages

Answer 3

IFN-gamma

Question 4

NK cells activated by antibody can kill via ________

Answer 4

ADCC

Question 5

NK cells activated by their activation receptors can cause ____________

Answer 5

cytotoxicity

Question 6

________ macrophages important in tumor immunity

Answer 6

M1

Question 7

Tumor antigens, IFN-gamma (from T cells and NK cells), and microbial products (LPS) can activate

Answer 7

macrophages

Question 8

M1 macrophages have cytotoxic molecules that can be _________________ on tumor cells or act on __________ tumor cells

Answer 8

Released directly

phagocytosed

Question 9

M1 macrophages can secrete ____________, which causes thrombosis of tumor blood vessels

Answer 9

TNF (tumor necrosis factor)

Leads to tumor necrosis

Question 10

Most important adaptive immune response to tumors is ________

Answer 10

CD8 cytotoxic T cell response

Question 11

Tumor antigens or cells are ingested by ______. Peptides derived from antigens are presented by MHC ___________.
CD8 naive T cells recognize tumor peptide/MHC _______
CD4 Thelper cells are activated to produce cytokines by peptide/MHC ________.
Drives differentiation of CD8 T cells.

What is process called?

Answer 11

APC
Classes 1 and 2
Class 1
Class 2

Cross Priming

Question 12

Once differentiated, do Cytotoxic T cells need costimulation to kill tumor cells?

Answer 12

No

Question 13

Tumor cells can evade immune attack by expressing inhibitory ________

Answer 13

surface proteins and cytokines

Question 14

Tumor cells ___________ Tregulatory cells

Answer 14

recruit

Question 15

Loss of MHC class 1 expression and tumor antigen that initially caused cytotoxic T cell differentiation can cause

Answer 15

Lack of T cell recognition

Question 16

APC at tumor site not fully activated, express low levels of

Answer 16

B7

Question 17

B7 binds to ______ to form an inhibitory signal

Answer 17

CTLA-4

Question 18

Some tumor cells express ______ that can attenuate the activation of cytotoxic T cells

Answer 18

PD-L1

Question 19

TGF-beta is a _______ cytokine

Answer 19

inhibitory

Question 20

Many tumor cells secrete

Answer 20

TGF-Beta (inhibitory cytokine)

Question 21

NK inhibitory receptors recognize

Answer 21

MHC class 1

Question 22

Tregulatory cells are small population of ________

Answer 22

CD4 T cells

Question 23

Prevent autoimmune and allergic disease by suppressing immune responses to auto-antigens and allergens

Answer 23

Tregulatory cells

Question 24

Tumors recruit _________ to tumor site to suppress immune responses to tumor antigens

Answer 24

Treg

Question 25

_____CD8 _____Treg cells Poor prognosis

Answer 25

Low | High

Question 26

Tumor vaccines, blocking inhibitory pathways, and co-stimulators and cytokines are part of __________ strategies

Answer 26

Active

Question 27

Antibodies to CTLA-4 and PD-L1 would ______________

Answer 27

block inhibitory pathways

Question 28

Co-stimulatory molecules and cytokines often _______ immune response so used in vaccines

Answer 28

enhance

Question 29

Adoptive cell transfer and anti-tumor antibodies are used in _________

Answer 29

passive immunotherapy

Question 30

Lymphokine activated killer (LAK) cells are ______ expanded and acted on by ______

Answer 30

NK cells | IL-2

Question 31

Can be obtained from patients and expanded with inactivated tumor cells and IL-2. Enriched for tumor specific cytotoxic T cells

Answer 31

Tumor infiltrating lymphocytes

Question 32

In graft versus leukemia effect, lymphocytes from healthy donors mount immune response against cancer patient's ________, which causes recipient's _______ cells to be attacked

Answer 32

MHC | Leukemia

Question 33

Anti-tumor antibodies conjugated with _________ or ________

Answer 33

toxins | radioisotopes