thyroid hormones

Question 1

diagnosis of hypo/hyperthyroidism

Question 2

goals of therapy- hypo

Question 3

signs and symptoms hypo

Question 4

dose for LT4

Answer 4

1-1.6mcg/kg/day

Question 5

drugs that affect metabolism of LT4

Answer 5

antiepileptics, rifampin and pregnancy

Question 6

explain the thyroid function monitoring of T4

Answer 6

serum TSH testing
- every 6-12 months of if a change in clinical status is noticed
- 6-8 weeks after dose or products change
- as soon as possible in pregnancy then monthly

Question 7

dose in myxedema

Answer 7

IV LT4 400–500 mcg × 1 in patients <55 years without cardiac disease

Question 8

dose of propranolol

Answer 8

Initial propranolol dose of 20 - 40 mg 4 x daily should be titrated to relieve S & S (target resting HR ˂ 90 bpm).

Question 9

KI dose and starting dose

Answer 9

Potassium iodide is administered either as a saturated solution (contains up to 50 mg iodide / drop) or as Lugol’s solution (contains up to 8 mg iodide /drop)
The typical starting dose is 120 - 400 mg iodide / day.
Iodide therapy should be started 7 - 14 days before surgery.

Question 10

MOA of thionamides?

Answer 10

inhibit thyroid hormone synth
PTU inhibits conversion of t4 to t3
immunosuppressant effects

Question 11

half life of RAI

Answer 11

8 days