Thyroid Drugs (blue highlights only)

Question 1

Indication for propanolol (thyroid)

Answer 1

widely used to reduce heart rate and tremor during thyroid storm

Question 2

MOA propanolol

Answer 2

inhibits conversion of T4 to T3, which occurs in peripheral tissues; may help reverse reduced SVR

Question 3

Methimazole MOA

Answer 3

blocks iodide organification by inhibiting TPO (like all thioamides)

Question 4

Most sensitive screening test for hyperthyroidism and primary hypothyroidism

Answer 4

TSH (if in normal ranges, these Dx are excluded)

Question 5

Drug that impairs levothyroxine absorption

Answer 5

cholestyramine

Question 6

When is radioactive iodine therapy for thyroid cancer contraindicated?

Answer 6

in pregnancy

Question 7

indications atenolol

Answer 7

hyperthyroidism!

• graves disease
• thyroid storm

Question 8

MOA perchlorate

Answer 8

inhibits thyroid hormone production by blocking the sodium/iodine symporter

Question 9

How to control amiodarone-induced thyroid dysfunction

Answer 9

perchlorate

Question 10

Rare, serious toxicity associated with thioamides (methimazole) ?

Answer 10

agranulocytosis