thyroid disorders Flashcards
what blood findings would you expect in hypothyroidism & myxedema
anemia, hyponatremia, hyperlipidemia, low FT4, and elevated TSH
what symptoms would you expect in hypothyroidism and myxedema
weakness, fatigue, cold intolerance, constipation, wt change, depression, menorrhagia, hoarseness
what signs would you expect to find in hypothyroidism and myxedema
dry skin, bradycardia, delayed return of DTR, menorrhagia, hoarsenes
would you expect to find the TSH level elevated or depressed in primary hypothyroidism
TSH should be elevated
T/F hypothyroidism may be due to failure or resection of the thyroid gland itself or deficiency of pituitary PTH
true or can be functional as in severe nonthyroidal illness
what are some drugs that can cause hypothyroidism
chemotherapeutic agents- radioiodine based, amiodarone (high iodine content), interferon
what is associated with an increased risk of autoimmune thyroiditis (antithyroid antibodies) leading to hypothyroid
Hepatitis C
what are 2 common syndromes seen in hypothyroidism
carpal tunnel and raynaud
what would hypothyroid look like
puffy face, eyes, frowzy hair, and dull apathetic appearance
how can hypothyroid affect your senses
decreased sense of taste, smell, and diminished auditory acuity
what is the single best screening test for hypothyroidism
serum TSH
over 95% of normal adults have a serum TSH under ___
3.0mU/L
what is the preferred Tx for hypothyroidism
synthetic levothyroxine
what is a complication of levothyroxine therapy
it can exacerbate HF in preexisting CAD
pts with severe hypothyroidism have an increased susceptibility to ___
bacterial pneumonia
what are some key symptoms of hyperthtroidism
sweating, wt change, anxiety, palpitations, loose stool, heat intolerance, irritability, weakness, menstrual irregularity
what are some key signs of hyperthyroidism
tachycardia, warm moist skin, stare, tremor
what are some key findings in Graves dz
goiter -often with bruit, opthalmopathy (exopthalamus/ proptosis, lid lag)
in hyperthyroidism what would you expect to find hormonally
suppressed TSH in primary, inc T3,4 and FT3,4
what is Graves dz
autoimmune disorder affecting the thyroid gland, characterized by an inc synth and release of thyroid hormone
multiple autonomous toxic adenomas of the thyroid are seen in what Dz
toxic multinodular goiter
subacute thyroiditis AKA “de Quervain or granulomatous” is typically caused by ___
viral infections
what are some S/S of subacute throiditis
extremely painful thyroid, tender to touch, enlarged 3-4x, dysphagia and pain - can radiate to jaw or ear
a high RAI uptake is seen in
Graves dz and toxic nodular goiter
a low RAI uptake is seen in
subacute thyroiditis
what are some complications of hyperthyroidism
hypercalcemia, osteoporosis, nephrocalcinosis, arrhythmias and HF
T/F propranolol is generally used for symptomatic relief of hyperthyroidism
true
how is toxic multinodular goiter treated
propranolol ER and methimazole
what autoimmune condition is the most common thyroid disorder in the US where B- lymphocytes invade the thyroid gland
Hashimoto thyroiditis
how does PTH maintain plasma Ca
by direct actions on kidney, bone and activating vit D
T/F bone is a calcium and phosphorus reservoir
true
in the kidney what effect does PTH have
inc Ca resorption; inc phosphate excretion; activates Vit D
does PTH inc or dec in low Ca and low Vit D
increase
