Thyroid and Parathyroid Hormone Laboratory Flashcards

1
Q

The most useful test for assessing thyroid function

A

THYROID-STIMULATING HORMONE

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2
Q

immunometric assays effectively screen for
hyperthyroidism

A

Second-generation TSH

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3
Q

chemiluminometric assays give fewer false-negative
results and more accurately distinguish between
euthyroidism and hyperthyroidism

A

Third-generation TSH

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4
Q

chemiluminometric assays give fewer false-negative
results and more accurately distinguish between
euthyroidism and hyperthyroidism

A

Third-generation TSH

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5
Q

exists providing a 10-fold increase in sensitivity
compared to third-generation assays

it is used primarily for research purposes

A

Fourth-generation assay

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6
Q

reference range for s-TSH

A

s 0.3–4.2 mIU/L

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7
Q

Measured by chemiluminometric assay or similar
immunometric technique

A

THYROXINE (T4)

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8
Q

reference range for T4

A

0.4–4.0 mIU/L

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9
Q

composed of both bound and free fractions

A

TRIIODOTHYRONINE (T3)

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10
Q

reference range for total T3

A

80–200 ng/dL

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11
Q

It is used as a second-line test after TSH in the evaluation of
suspected thyroid disorders and when used in conjunction with
TSH

A

FREE THYROXINE (FT4)

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12
Q

FT3 levels may be required to evaluate clinically euthyroid
patients who have an altered distribution of thyroid binding
proteins as seen during ____________ or in patients with
__________________.

A

pregnancy
dysalbuminemia

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13
Q

Reference range for FT3

A

2.8–4.4 pg/mL

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14
Q

LOW FREE T4
LOW TSH

A

Secondary
hypothyroidism

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15
Q

NORMAL FREE T4, LOW TSH

A

Subclinical
hyperthyroidism

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16
Q

NORMAL FREE T4
LOW TSH

A

Subclinical
hyperthyroidism

17
Q

HIGH FREE T4
LOW TSH

A

Primary
hyperthyroidism

18
Q

LOW FREE T4
Normaal TSH

A

Secondary
hypothyroidism

19
Q

NORMAL FREE T4
Normaal TSH

A

Normal

20
Q

HIGH FREE T4
Normaal TSH

A

Secondary
hyperthyroidism

21
Q

NORMAL FREE T4
Highl TSH

A

Subacute
hypothyroidism

22
Q

LOW FREE T4
Highl TSH

A

Primary
hypothyroidism

23
Q

NORMAL FREE T4
Highl TSH

A

Subclinical
hypothyroidism

24
Q

HIGH FREE T4
Highl TSH

A

Secondary
hyperthyroidism

25
Q

Anti-Tg autoantibodies are most commonly associated with
_____________?

A

hashimoto’s thyroiditis

26
Q

reference range for thyroglobulin antibodies

A

s <4.0 IU/mL

27
Q

the most sensitive test for detecting autoimmune thyroid diseases including Hashimoto’s thyroiditis and Graves’ disease

A

THYROPEROXIDASE ANTIBODY

28
Q

reference range for TPO autoantibodies

A

s <9.0 IU/mL

29
Q

Most closely associated with disease pathogenesis

A

THYROTROPIN RECEPTOR ANTIBODY

30
Q

THYROTROPIN RECEPTOR ANTIBODY also known as___________________ or______________?

A

Long-acting thyroid stimulator (LATS) or thyroid-stimulating immunoglobulins
(TSI)

31
Q

reference range for TRAb

A

≤1.75 IU/L

32
Q

Common PTH assays use a _______________ in which two
antibodies bind to specific sites on the PTH molecule

A

sandwich technique

33
Q

solid phase antibody binds to the

A

e C-terminal end

34
Q

Signal antibody binds

A

N-terminal ends

35
Q

Measures the entire 1 to 84 PTH
sequence.

A

SANDWICH ELISA or electrochemiluminescent PTH
(intact, whole)

36
Q

This assay detects biologically active PTH
by its ability to induce formation of cAMP

A

CAP ASSAY

37
Q

There is no crossreactivity. Therefore, PTH
levels are low in subjects with cancers
producing PTHrP.

A

PTHRrP ASSAYS and PTH ASSAYS

38
Q

Test used for specimens obtained from parathyroid tumors.

A

Fine needle aspiration or needle biopsy