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GI, Liver, Metabolic PHARM > Thyroid and Bone Hormones/Gonadotropic Hormones and Antagonists > Flashcards

Thyroid and Bone Hormones/Gonadotropic Hormones and Antagonists Flashcards

1
Q

methimazole, propylthiouracil USE

A

hyperthyroidism- shrink thyroid, control until thyroidectomy

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2
Q

methimazole, propylthiouracil MOA

A

block peroxidase-mediated iodination of thyroglobulin, inhibiting organification of iodide and coupling of thyroid hormone synthesis
Propylthiouracil also blocks 5’ deiodinase which decreases peripheral conversion of T4 to T3
return pt to euthyroid state before long term option
meth preferred to PTU when radioactive iodine is needed bc doesnt inhibit uptake

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3
Q

methimazole, propylthiouracil TOX

A 
skin rash
agranulocytosis- rare
aplastic anemia
HEPATOTOXICITY- propylthiouracil
methimazole-possible teratogen
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4
Q

radioactive iodine MOA

A

taken up by thyroid cells for destruction

most efective when patients have high TSH

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5
Q

radioactive iodine TOX

A

neck tenderness and swelling
N/V
swelling/tenderness of salivary glands

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6
Q

L-thyroxine

A

used in striaghtforward hormone replacement in hypothyroidism

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7
Q

Primary regulators of bone homeostasis

A

PTH- increase serum Ca2+, decrease PO4
Calcitriol (active Vit. D)- increase Ca2 and PO4
Both affect GI tract, Kidney and Bone

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8
Q

Bisphosphonates drugs?

A

alendronate
ibandronate
risedronate
etidronate

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9
Q

Bisphosphonate MOA

A

inhibit osteoclastic activity- reducing formation and resorption of hydroxyapatite

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10
Q

Bisphosphonate USE

A

malignancy associated hypercalicemia
Paget’s disease of bone
postmenopausal osteoporosis- prophylax

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11
Q

Bisphosphonate TOX

A

erosive esophagitis
nausea, diarrhea, osteonecrosis of jaw
must be taken on empty stomach with full glass of water with pt upright for an hour

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12
Q

Raloxifene MOA

A

SERM- nonsteriodal approved for prevention and TREATMENT of osteporosis
decreases bone turnover

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13
Q

Teriparatide MOA

A

PTH analog- stimulates osteoblasts, increasing trabecular bone density and connectivity in postmenopausal women
opposite of estrogen and bisphos. which reduce osteoclastic activity

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14
Q

ET/EPT MOA

A

inhibit osteoCLASTIC bone resorption

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15
Q

Calcitonin MOA

A

inhibits osteoCLASTIC bone resorption

inhibits kidney tubular reabsorption of Ca and PO4

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16
Q

Glucocorticoids- bone effects?

A

antagonize Vit. D mediated GI absorption of Ca and PO4
partially block reab of Ca and PO4
enhance PTH-mediated bone resorption

17
Q

Vit D/ Ca supplements

A

treatment for hypocalecemia, overdose can lead to stone formation

GI, Liver, Metabolic PHARM (6 decks)

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