Thyroid

Question 1

What are transient thyroid conditions?

Answer 1

Euthyroid Sick Syndrome; Low t3, low to normal t4, Normal TSH

Transient Hypothyroxinemia of Prematurity; decreased thyroid levels without elevated TSH; related to immaturity; Low t4 and Free T4 and normal to slightly low TSH

Question 2

What is congenital hypothyroidism?

Answer 2

Significant decrease or absence of thyroid function at birth.

If not corrected will lead to mental retardation.

Question 3

How do you treat congenital hypothyroidism?

Answer 3

Levothryoxine

Question 4

What causes congenital Hypothyroidism?

Answer 4

Low maternal iodine consumption
Primary thyroid defect
Inborn error of metabolism

Question 5

What is Neonatal Thyrotoxicosis?

Answer 5

Hyper metabolic state with excessive thyroid activity.

Results from transplacental passage of thyroid hormone in mother with GRAVES or HASHIMOTO

Question 6

What is the first manifestation of Thyrotoxicosis?

Answer 6

Fetal Tachy in the third trimester

Question 7

How do you treat Neonatal Thyrotoxicosis?

Answer 7

Mild: monitor

Moderate: Lugols Solution, Methimazole, PTU

Severe: Prednisone, propanolol, human IV immunoglobulin