Thyroid Flashcards
Thyroid hormones?
TH
Calcitonin
Thyroglobulin (Tg) is?
protein for synth/storage of T3/4
Thyroxine is?
T4
Thyroxine Binding Globulin (TBG)?
Binds T4 for transport thru blood
Hypothyroid sxs: from metabolic slowing?
cold intoler fatigue/weak slow speech/movement bradycard weight gain sustained DTR
Hypothyroid sxs: from ↑ matrix?
dry skin facial edema large tongue hair loss hoarseness
Hypothyroid sxs: other?
hearing loss aches/pains delayed puberty diastolic HTN ascites depression effusions
Hypothyroid labs?
TSH
FT4/T3
BMP
Lipids
Hypothyroid T4 and TSH lab results:
Primary?
Subclinical?
2º to Pitu/hypothal disorders?
Primary: T4 = Low, TSH = High
Sub: T4 = N, TSH = High
2º: T4 = Low, TSH = N
Risk factors for hypothyroid?
goiter autoimm radio iodine tx head/neck radiation FHx thyroid dz
Primary Hypothyroid caused by?
Hashimoto (autoimm)
Iatrogenic
Iodine issue
Hypothyroid tx?
Goal?
T4 replacement
Sxs relief
Normalize TSH
Shrink goiter
Hyperthyroid sxs?
heat intoler bulging eyes flushing tachycard systolic HTN weight loss mm wasting impaired glu tolerance dyspnea
Hyperthyroid causes: autoimmune?
Grave’s
Thyroiditis
Hyperthyroid causes: autonomous?
toxic adenoma
toxic goiter
Hyperthyroid causes: TSH?
TSH-producing pitu adenoma
Hyperthyroid lab findings?
TSH = Low T3 = High T4 = High
Hyperthyroid imaging?
24hr radioiodine scan
High uptake = de novo synth of TH
Low uptake = gland destruction or outside source of TH
TEST NOT FOR PREGGOS/NURSING
Hyperthyroid tx?
β-block
Thionamides
Radioiodine ablation
Surgery
Thyroid CA: poorer prognosis if?
Anaplastic
< 20 yo
> 45 yo
Male
Thyroid CA tx?
Surgery
TSH suppression (levothyroxine)
Radioiodine ablation
HypoPTH caused by?
(U) thyroidectomy
Autoimm
Congenital
HypoPTH signs/sxs?
tetany/cramps mental ∆s paresthesia of mouth/hands/feet stridor hypothyroid matrix sxs
HypoPTH lab findings?
serum/urine Ca2+ = Low
serum PO4 = High
PTH = Low
Mg (P) High
HypoPTH tx:
Emergency tetany?
Maintenance?
tetany: IV Ca2+ gluconate
Maint:
Ca2+/VitD
(P) Mg
NO lasix
Primary HyperPTH caused by?
(U) PT adenoma
hyperplasia or CA
2º HyperPTH caused by?
Renal fail (hyperPO4/low vitD prdxn = low Ca2+)
HyperPTH sxs?
Asymp hyperCa2+
or
bones, stones, abd moans, psychic groans
HyperPTH lab findings?
serum/urine Ca2+ = High
serum PTH = High
hyperPTH tx?
surgery
