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Q3 Clin Med II Final (Endocrine) > Thyroid > Flashcards

Thyroid Flashcards

1
Q

Thyroid hormones?

A

TH

Calcitonin

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2
Q

Thyroglobulin (Tg) is?

A

protein for synth/storage of T3/4

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3
Q

Thyroxine is?

A

T4

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4
Q

Thyroxine Binding Globulin (TBG)?

A

Binds T4 for transport thru blood

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5
Q

Hypothyroid sxs: from metabolic slowing?

A 
cold intoler
fatigue/weak
slow speech/movement
bradycard
weight gain
sustained DTR
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6
Q

Hypothyroid sxs: from ↑ matrix?

A 
dry skin
facial edema
large tongue
hair loss
hoarseness
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7
Q

Hypothyroid sxs: other?

A 
hearing loss
aches/pains
delayed puberty
diastolic HTN
ascites
depression
effusions
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8
Q

Hypothyroid labs?

A

TSH
FT4/T3
BMP
Lipids

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9
Q

Hypothyroid T4 and TSH lab results:

Primary?

Subclinical?

2º to Pitu/hypothal disorders?

A

Primary: T4 = Low, TSH = High

Sub: T4 = N, TSH = High

2º: T4 = Low, TSH = N

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10
Q

Risk factors for hypothyroid?

A 
goiter
autoimm
radio iodine tx
head/neck radiation
FHx thyroid dz
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11
Q

Primary Hypothyroid caused by?

A

Hashimoto (autoimm)
Iatrogenic
Iodine issue

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12
Q

Hypothyroid tx?

Goal?

A

T4 replacement

Sxs relief
Normalize TSH
Shrink goiter

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13
Q

Hyperthyroid sxs?

A 
heat intoler
bulging eyes
flushing
tachycard
systolic HTN
weight loss
mm wasting
impaired glu tolerance
dyspnea
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14
Q

Hyperthyroid causes: autoimmune?

A

Grave’s

Thyroiditis

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15
Q

Hyperthyroid causes: autonomous?

A

toxic adenoma

toxic goiter

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16
Q

Hyperthyroid causes: TSH?

A

TSH-producing pitu adenoma

17
Q

Hyperthyroid lab findings?

A 
TSH = Low
T3 = High
T4 = High
18
Q

Hyperthyroid imaging?

A

24hr radioiodine scan

High uptake = de novo synth of TH
Low uptake = gland destruction or outside source of TH

TEST NOT FOR PREGGOS/NURSING

19
Q

Hyperthyroid tx?

A

β-block
Thionamides
Radioiodine ablation
Surgery

20
Q

Thyroid CA: poorer prognosis if?

A

Anaplastic
< 20 yo
> 45 yo
Male

21
Q

Thyroid CA tx?

A

Surgery
TSH suppression (levothyroxine)
Radioiodine ablation

22
Q

HypoPTH caused by?

A

(U) thyroidectomy
Autoimm
Congenital

23
Q

HypoPTH signs/sxs?

A 
tetany/cramps
mental ∆s
paresthesia of mouth/hands/feet
stridor
hypothyroid matrix sxs
24
Q

HypoPTH lab findings?

A

serum/urine Ca2+ = Low
serum PO4 = High
PTH = Low
Mg (P) High

25
Q

HypoPTH tx:

Emergency tetany?

Maintenance?

A

tetany: IV Ca2+ gluconate

Maint:
Ca2+/VitD
(P) Mg
NO lasix

26
Q

Primary HyperPTH caused by?

A

(U) PT adenoma

hyperplasia or CA

27
Q

2º HyperPTH caused by?

A

Renal fail (hyperPO4/low vitD prdxn = low Ca2+)

28
Q

HyperPTH sxs?

A

Asymp hyperCa2+
or
bones, stones, abd moans, psychic groans

29
Q

HyperPTH lab findings?

A

serum/urine Ca2+ = High

serum PTH = High

30
Q

hyperPTH tx?

A

surgery

Q3 Clin Med II Final (Endocrine) (6 decks)

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