Thyroid

Question 1

Thyroid hormone preparation

Answer 1

Levothyroxine

Question 2

Antithyroid agents

Answer 2

Thiomazole(methimazole), propylthiouracil

Question 3

Iodide is oxidised to iodine by

Answer 3

Thyroid peroxidase

Question 4

Iodine +thyroxine residue in presence of thyroid peroxidase produce

Answer 4

Monoiodothyroxine and at the end diiodothyroxine

Question 5

Monoiodothyroxine and diiodothyroxine are also conjugated by

Answer 5

Thyroid peroxidase

Question 6

—%of T3 is formed in thyroid gland

Answer 6

10

Question 7

T4 is converted to T3 in the periphery by

Answer 7

Iodothyronine deiodinase

Question 8

T3 is —X active than T4

Answer 8

10

Question 9

Thyroid hormone function

Answer 9

Energy or heat production regulations,increase gluconeogenesis and decrease glycogen synthesis,affect lipid metabolism,Somatic growth,Nervous system functioning and development, stimulation of beta adrenergic receptor expression and increase sensitivity to catecholamines

Question 10

Common causes of hypothyroidism

Answer 10

Hyperthyroidism treatment,chronic autoimmune thyroiditis, thyroid gland surgery, medications like lithium and amiodarone

Question 11

Common causes of hyperthyroidism are

Answer 11

Graves (Bazedovs) Disease, nodular toxic goiter

Question 12

Treatment for hyperthyroidism

Answer 12

Radioactive iodine therapy or thyrostatic drug therapy

Question 13

T4 synthesis needs

Answer 13

Low iodine concealer

Question 14

Carbimazol

Answer 14

Thiomazole prodrug

Question 15

Levothyroxine use

Answer 15

Hypothyroidism, autoimmune (hashimoto’s) thyroiditis, replacement therapy after thyroidectomy

Question 16

SE of levothyroxine

Answer 16

Tachycardia

Question 17

Levothyroxine should be taken

Answer 17

60 min before 1st meal and no other medications in 2-4 hr

Question 18

Levothyroxine may reduce effect of

Answer 18

Hypoglycemic agrnts

Question 19

Mild and moderate intoxication of thyroid hormone cause

Answer 19

Sinus tachycardia,tremor, anxiety, feeling of heat, agitation and sleep disorders

Question 20

Severe toxicity of thyroid hormone cause

Answer 20

Supraventricular tachycardia, hypertension, hyperthermia

Question 21

Symptoms of levothyroxine overdose appear only in

Answer 21

7 days approx

Question 22

In case of strong adtenostimulation by levothyroxine use

Answer 22

Propranalol

Question 23

Thiomazole inhibit

Answer 23

Thyroxine peroxidase

Question 24

Thiomazole cross placenta,so it is

Answer 24

Embryotoxic

Question 25

Propylthiouracil inhibits both

Answer 25

Thyroid peroxidase and iodothyronine deiodinase

Question 26

Propylthiouracil can be used in the first trimester of pregnancy because it is

Answer 26

10 x weaker than thiomazole

Question 27

Propylthiouracil and thiomazole use

Answer 27

Hyperthyroidism like in graves disease

Question 28

SE of thiomazole and propylthiouracil

Answer 28

Allergic skin reaction, agranulocytosis