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Lab Medicine > Thyroid > Flashcards

Thyroid Flashcards

1
Q

Where does parathyroid hormone work?

A

Bone and kidney

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2
Q

How is PTH stimulated?

A

Decreased of Calcium and increased of PO4

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3
Q

What does PTH do?

A

-Stimulates osteoclastic bone resorption
-Stimulates bone formation that is couple to bone resorption
-Increases renal tubular reabsorption of Calcium*
-Enhances renal elimination of phosphates*

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4
Q

What do thyroid C cells do?

A

The opposite of PTH
-inhibits osteoclast resorption
-delays Calcium absorption from intestine
-Increases calcium urinary excretion

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5
Q

How are c cells in the thyroid stimulated?

A

High blood calcium

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6
Q

Where does thyroid hormone synthesis occur?

A

Follicules

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7
Q

What hormone are follicular cells under control of?

A

TSH

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8
Q

Where are thyroid hormones stored in?

A

Gelatinous protein colloid

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9
Q

What organ uses iodine?

A

Thyroid

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10
Q

What portion of the iodine is absorbed?

A

1/3 of diet iodine goes to thyroid, the rest is excreted by kidney

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11
Q

Iodide binds to amino acid _ residues in the _ _.

A

tyrosine, thyroglobulin molecule

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12
Q

Where is the thyroglobulin molecule when its binding to iodide?

A

In the cell

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13
Q

Which thyroid hormone is produced more?

A

T4 = 97%

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13
Q

Which thyroid hormone is produced more?

A

T4 = 97%

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14
Q

T4 goes where after being synthesized?

A

Liver- turns into T3 and rT3 inactive form of T3

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15
Q

Which thyroid hormone is most biologically active?

A

T3

16
Q

What transporter portion for thyroid hormones is created in liver?

A

TBH thyroid binding globulin- it can determine your levels of free T3 and T4

17
Q

What is the function of thyroid hormones?

A

Biological catalyst- oxidative and metabolic reactions
T3 controls 50 of the metabolism and T4 the other half.

Growth & maturation of skeletal system
Decrease- short, delayed maturation
Increase- increased osteoclastic bone resorption and bone less

18
Q

What is most common impairment of endocrine system?

A

Thyroid hormones

19
Q

What is the first strategy of thyroid function tests in the US?

A

Pituitary TSH

Lab Medicine (2 decks)

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