Thrombotic Thrombocytopaenic Purpura

Question 1

What is Thrombotic Thrombocytopaenic Purpura?

Remember that it is a pentad.

Answer 1

Thrombotic Thrombocytopaenic Purpura is a pentad of:

Fever

Microangiopathic Haemolytic Anaemia

Thrombocytopaenia

Abnormal Renal Function

Central Nervous System Changes

Reference: Nelson’s Paediatrics [20th Edition], p. 2404.

Image Source: https://www.pinterest.com/pin/562738915929091725/

Question 2

How is TTP treated?

Answer 2

The principal treatment for TTP is Plasma Exchange.

Refractory cases may required Rituximab, Corticosteroids, and Splenectomy.

Question 3

What causes TTP?

Answer 3

Most cases result from deficiency of the metalloproteinase ADAMTS-13.

Reference: Nelson’s Paediatrics [20th Edition], p. 2404.