Thrombosis Flashcards
How do you treat an arterial thrombosis
Aspirin and other anti-platelet drugs
Modify risk factors for atherosclerosis
How does an arterial thrombosis occur
Formation of atherosclerotic plaques - narrows the vessel and can cause hypoxia
In a high pressure system this has risk of rupture which then starts the clotting cascade
Clots can completely block of the vessel - MI etc
How does a venous thrombus occur
Stasis is the problem
The platelets aren’t activated as its a low pressure system so less risk of damage
Fibrin clots form due to hypercoagulability (more clotting factors)
What is Virchow’s triad
Stasis
Vessel wall issues
Hypercoagulability
increases risk of venous thrombosis
Arterial thrombi are rich in what
Platelets
Venous thrombi are rich in what
Fibrin
How do you treat venous thrombosis
Anti-coagulants
Heparin, Warfarin or the new oral anticoagulants
How does DVT present
Limb feels hot, swollen, tender.
Pitting oedema
What are the risk factors for venous thromboembolism
Age Marked obesity Pregnancy Puerperium Oestrogen therapy Previous DVT/PE Trauma/Surgery Malignancy Paralysis/immobility Infection Thrombophilia
How does pregnancy affect clotting factors
Factor 8 levels rise x3 during pregnancy - hypercoagulable state
HRT or OCP tricks body into thinking its pregnancy (oestrogen) so CF raise with these too
What is a thrombophilia
Familial or acquired disorder of the haemostatic mechanism which are likely to predispose to thrombosis.
Most are due to a decrease in anticoagulant activity
How do hereditary thrombophilia’s present
Recurrent thromboses at a younger age than expected
List common hereditary thrombophilia’s
Factor V Leiden - Protein C and S less effective at switching off factor 5 Prothrombin 20210 mutation Antithrombin deficiency Protein C deficiency Protein S deficiency
When should you consider screening someone for hereditary thrombophilia
Venous thrombosis <45 years old Recurrent venous thrombosis Unusual venous thrombosis Family history of venous thrombosis Family history of thrombophilia
How do you manage hereditary thrombophilia
Advice on avoiding risk
Short term prophylaxis during periods of known risk
Short term anticoagulation to treat thrombotic events
Long term anticoagulation if recurrent thrombotic events
What factors from the history suggest a risk of recurrent thrombosis
Strongest risk = personal Hx of thrombosis
Spontaneous event - rather than brought on by surgery or immobility
Family history
What is antiphospholipid syndrome
Produce autoantibodies against a protein causing increased tendency for thrombosis
Activates both primary and secondary haemostasis
What are the features of antiphospholipid syndrome
Recurrent thromboses Arterial, including TIAs Venous Recurrent foetal loss Mild thrombocytopenia
Why does antiphospholipid syndrome lead to miscarriage
Thrombosis in placenta prevents the baby from receiving what it needs to grow and survive
Will have recurrent miscarriage
What other conditions are associated with antiphospholipid antibodies (apart from anti-phospholipid syndrome)
Associated with other autoimmune disorders
EBV can act as a trigger
Lymphoproliferative Disorders
Drugs causing antibodies;
How do you treat anti-phospholipid syndrome
Treatment depends upon location of bloodclot
Arterial = antiplatelet (aspirin)
Venous = anticoagulant (warfarin)
What are the indications for anti-coagulants
Venous thrombosis
Atrial fibrillation
How is heparin administered
IV or SC
How does heparin work
Potentiates antithrombin - stabilises its complex with thrombin
Has an immediate effect
What are the 2 forms of heparin
Unfractioned
Low molecular weight - LMWH