Thrombophillia

Question 1

What’s normal homeostasis

Answer 1

Maintain Blood - fluid statel clot free in vasculatare only form the homeostatic plug at injury sites

Question 2

How homeostasis balance lies

Answer 2

Balance between procoaqulent and anticoagulant mechanism

Question 3

What are 2 types of thrombphillia disorders

Answer 3

Inherited disorders & acquired disorders

Question 4

What are thrombi

Answer 4

Solid mass or plug formed in circulating blood

Question 5

What’s components of basic structure of thrombin

Answer 5

Platelets and fibrin

Question 6

What’s Virchow’s triad

Answer 6

Endothelial injury/
Disturbances of blood flow
Nupercocgutability

Question 7

To what arterial throb sis related?

Answer 7

Atherosclerosis J

endothelial damage and turbulence

Question 8

What are the risk factors for arterial thrombosis

Answer 8

Positive family hx.

Males

Hyperlipidemia 
Dm
Hypertension
Hyperhomocyteinaemia
Polyctethemia
Cigarette smoking
Polycythemia
Antiphospholipid syndrome

Question 9

Venous thrombosis based on?

Answer 9

Virchow’s triad

Increased coagulability/venous stasis

Question 10

What’s increased coagulability

Answer 10

Increased coagulation pathway activity

Decreased inhibition of coagulation activity

Question 11

What are the physiological limitation of bloodCoagulation

Answer 11

Tissue factor pathway inhibitor
antithrombin
Protein CNS pathway

Question 12

What will we do by tissue factor ParthwY inhibitor

Answer 12

Present in plasma n platelet
Accumulated the site of platelet activation
Inhibit activated factor 10 and seven

Question 13

What is the action of the antithrombin

Answer 13

Inactivates thrombin and other serine proteases

Question 14

What are hereditary risk factors for venous Thrombosis

Answer 14

Factor five Leiden
Protein c deficiency 
Antithrombin deficiency
Protein S deficiency
Abnormal fibrinogen and increase fibrinogen 

Question 15

What are acquired disorders of Venus thrombosis thrombosis

Answer 15

Antiphospholipid syndrome
Estrogen therapy 
heparin Induced thrombocytopenia
Pregnancy
Surgery abdominal hip and knee surgery
Major trauma
Malignancy
Acute ill hospitalized medical patients
Milo proliferative disease 
Hyper viscosity polycythemia
Stroke
 pelvic obstruction
Nephrotic syndrome
Dehydration
Vericose vein 
Previous superficial vein  thrombosis
Age
Obesity 
PNH

Question 16

What are three essential features of antiphospholipid syndrome

Answer 16

occurrence of thrombosis

recurrent pregnancy loss

laboratory evidence of persistent antiphospholipid antibody

Question 17

What are additional clinical and laboratory features

Answer 17

Mild thrombocytopenia
Prolonged aPTT
Skin manifestations Livedo reticularis
Valvular abnormalties

Question 18

What is the diagnostic criteria for antiphospholipid syndrome

Answer 18

There must be at least one clinical and at least one laboratory criterion percent

Question 19

What are the clinical criteria is for antiphospholipid syndrome

Answer 19

Thrombosis – arterial or venous

Pregnancy complications 

Question 20

What are pregnancy complications of antiphospholipid syndrome

Answer 20

Morphologically normal fetus more than 10 weeks unexplained death

Three or more consecutive miscarriages less than 10 week unexplained

One normal or more premature births which are morphologically Normal fetus less than 34 weeks due to preeclampsia eclampsia 000 Severe placental insufficiency

Question 21

What A laboratory diagnosis of Antiphospholipid antibody’s

Answer 21

Coagulation based test

Immunoassays

Question 22

What a coagulation test for antiphospholipid antibody

Answer 22

Prolong aPTT but normal APTT do not exclude APS

DRVVT is more specific

Question 23

What are two immunoassays for antiphospholipid antibody’s

Answer 23

Anti-cardiolipin antibody

Anti2 glycoprotein antibody