Thrombophillia Flashcards
What’s normal homeostasis
Maintain Blood - fluid statel clot free in vasculatare only form the homeostatic plug at injury sites
How homeostasis balance lies
Balance between procoaqulent and anticoagulant mechanism
What are 2 types of thrombphillia disorders
Inherited disorders & acquired disorders
What are thrombi
Solid mass or plug formed in circulating blood
What’s components of basic structure of thrombin
Platelets and fibrin
What’s Virchow’s triad
Endothelial injury/
Disturbances of blood flow
Nupercocgutability
To what arterial throb sis related?
Atherosclerosis J
endothelial damage and turbulence
What are the risk factors for arterial thrombosis
Positive family hx.
Males
Hyperlipidemia Dm Hypertension Hyperhomocyteinaemia Polyctethemia Cigarette smoking Polycythemia Antiphospholipid syndrome
Venous thrombosis based on?
Virchow’s triad
Increased coagulability/venous stasis
What’s increased coagulability
Increased coagulation pathway activity
Decreased inhibition of coagulation activity
What are the physiological limitation of bloodCoagulation
Tissue factor pathway inhibitor
antithrombin
Protein CNS pathway
What will we do by tissue factor ParthwY inhibitor
Present in plasma n platelet
Accumulated the site of platelet activation
Inhibit activated factor 10 and seven
What is the action of the antithrombin
Inactivates thrombin and other serine proteases
What are hereditary risk factors for venous Thrombosis
Factor five Leiden Protein c deficiency  Antithrombin deficiency Protein S deficiency Abnormal fibrinogen and increase fibrinogen 
What are acquired disorders of Venus thrombosis thrombosis
Antiphospholipid syndrome Estrogen therapy heparin Induced thrombocytopenia Pregnancy Surgery abdominal hip and knee surgery Major trauma Malignancy Acute ill hospitalized medical patients Milo proliferative disease Hyper viscosity polycythemia Stroke pelvic obstruction Nephrotic syndrome Dehydration Vericose vein Previous superficial vein thrombosis Age Obesity PNH
What are three essential features of antiphospholipid syndrome
occurrence of thrombosis
recurrent pregnancy loss
laboratory evidence of persistent antiphospholipid antibody
What are additional clinical and laboratory features
Mild thrombocytopenia
Prolonged aPTT
Skin manifestations Livedo reticularis
Valvular abnormalties
What is the diagnostic criteria for antiphospholipid syndrome
There must be at least one clinical and at least one laboratory criterion percent
What are the clinical criteria is for antiphospholipid syndrome
Thrombosis – arterial or venous
Pregnancy complications 
What are pregnancy complications of antiphospholipid syndrome
Morphologically normal fetus more than 10 weeks unexplained death
Three or more consecutive miscarriages less than 10 week unexplained
One normal or more premature births which are morphologically Normal fetus less than 34 weeks due to preeclampsia eclampsia 000 Severe placental insufficiency
What A laboratory diagnosis of Antiphospholipid antibody’s
Coagulation based test
Immunoassays
What a coagulation test for antiphospholipid antibody
Prolong aPTT but normal APTT do not exclude APS
DRVVT is more specific
What are two immunoassays for antiphospholipid antibody’s
Anti-cardiolipin antibody
Anti2 glycoprotein antibody

