Thrombophilia OME

Question 1

clotting factors made by liver? anti-clotting factors?

Answer 1

2, 7, 9, 10

protein S, which is modified to protein C

Question 2

what’s factor II? IIa?

Answer 2

prothrombin

thrombin

Question 3

what’s factor I? Ia?

Answer 3

fibrinogen

fibrin

Question 4

what’s the purpose of protein C?

Answer 4

to inhibit factor V (which catalyzes the creation of factor IIa/thrombin)

Question 5

what’s the purpose of thrombin?

Answer 5

to catalyze the modification/activation of fibrinogen to fibrin

Question 6

what’s the MC clotting disorder?

Answer 6

FVL

Question 7

risk of clots: FVL vs cancer vs surgery/trauma

Answer 7

FVL = 1.5x
cancer = 20x
surgery/trauma = 10x

Question 8

what are the two pathways of the clotting cascade?

Answer 8

intrinsic and extrinsic

Question 9

what’s APS?

Answer 9

anti-phospholipid antibody syndrome

• lupus anticoagulant causes clots in body
• arterial and venous clots
• diagnosis: russel viper venom assay
• tx: Warfarin (INR: 2-3)

Question 10

what’s FVL?

Answer 10

factor V Leiden

• mutation of factor V makes it unresponsive to control mechanisms, this causes persistent activation of clotting cascade
• 1.5x increased risk of clotting (mild inc)