Thrombophilia

Question 1

Diagnostic criteria for APS (2 clinical, 3 labs)

Answer 1

vascular thrombosis
Pregnancy morbidity
Anti-CL Abs IgG or IgM >99th %ile
Anti-B2 gp1 IgG or IgM >99th %ile
Lupus anticoagulant

Question 2

Diagnostic criteria for catastrophic APS (4)

Answer 2

Evidence of 3 or more organ systems
Symptoms develop simultaneously or within 1 week
Histopathologic confirmation of small vessel occlusion in 1 organ
Presence of APL antibodies

Question 3

Treatment for catastrophic APS

Answer 3

Steroids
Anticoagulation (hep gtt, then warfarin)
If severe, add PLEX (if MAHA)
Then can do IVIG after PLEX

Question 4

3 causes of acquired antithrombin deficiency

Answer 4

Liver disease
heparin
acute thrombosis

Question 5

Inpatient Treatment of patient with antithrombin deficiency who develops acute, symptomatic VTE

Answer 5

Argatroban or
ATIII replacement products plus heparin

Question 6

Outpatient treatment for patient with antithrombin deficiency and acute, symptomatic VTE (2)

Answer 6

DOAC
Warfarin

Question 7

protein C deficiency increases the risk of what complication from warfarin?

Answer 7

skin necrosis

Question 8

Causes of acquired protein C or S deficiency? (5)

Answer 8

Liver disease
warfarin
estrogen, pregnancy
Inflammatory disease (S)
Acute thrombosis (S)