Thrombolytics Flashcards

1
Q

MOA in general of thrombolytic agents?

A

catalyze the formation of endogenous fibrinolytic plasmin (a serine protease) from it precursor plasminogen

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2
Q

Name some thrombolytic agents.

A

alteplase or tissue plasminogen activator (tPA), (recombinant)
streptokinase

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3
Q

Streptokinase MOA specifically.

A

Acts on both bound and free plasminogen (not clot specific) depleting circulating plasminogen and factors V and VIII

acts with plasminogen to produce an “activator complex” that converts plasminogen to the proteolytic enzyme plasmin

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4
Q

Where is streptokinase derived from?

A

foreign protein derived from B-hemolytic streptococci

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5
Q

When may you not want to use streptokinase as a thrombolytic agent in a patient?

A

it is antigenic and may cause a problem if a person has had a recent past use or infection - strep ab may decrease activity

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6
Q

MOA of alteplase. Why are there fewer allergic reactions with this drug than streptokinase?

A

Is clot specific acting mainly on fibrin-bound plasminogen, the natural activator, so few allergy problems

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7
Q

There is a decrease in mortality post MI if you use thrombolytics within what time frame?

A

within 3 hours

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8
Q

S/E streptokinase?

A

HSR

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9
Q

What is the antidote for thrombolytic agents?

A

aminocaproic and tranexamic acids

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