Thrombogenesis and related drugs Flashcards
1
Q
Action of aspirin
A
Irreversibly inhibits cyclooxygenase, thereby inhibiting TXA2 synthesis and thus aggregation of platelets
2
Q
Action of clopidogrel, prasugrel, and ticlopidine
A
Inhibit ADP-induced expression of GpIIb/IIIa via P2Y12 receptor
3
Q
____, ____ and ____ inhibit GpIIb/IIIa directly
A
Abciximab, eptifibatide, and tirofiban
Memory aid:
- aBciximaB has two Bs so GpIIb / IIIa inhibitor
- TEA affects GpIIb/IIIa
4
Q
____ activates vWF to bind GpIb
A
Ristocetin
5
Q
Disease
- GpIb deficiency
- vWF deficiency
- GpIIb/IIIa deficiency
A
- GpIb deficiency
- Bernard-Soulier syndrome
- vWF deficiency
- von Willebrand disease
- GpIIb/IIIa deficiency
- Glanzmann thrombasthenia
