Thrombocytosis

Question 1

What are the general causes of thrombocytosis

Answer 1

Due to one of three causes
• Iron deficiency, inflammation/cancer/infection, underlying myleoproliferative process
• Elevated platelet counts places a patient at risk for bleeding as VWF will remove platelets from circulation

Question 2

What is the patho behind VWD

Answer 2

Most common inherited bleeding disorder
VWF serves two purposes; the glue to hold platelets together and to bind protein for factor VIII, increasing its half-life

Question 3

What are the three subtypes of VWF

Answer 3

• Type One
o Increased APTT, decreased VWF antigen and activity, decreased VIII activity
• Type Two
o Increased APTT, decreased VWF antigen, large decrease in VWF activity, and decrease VIII activity
• Type Three
o Large increase in APTT, large decrease in VWF antigen/activity, and VIII activity

Question 4

Symptoms of VWD

Answer 4

• Mucosal bleeding, menorrhagia, menstrual bleeding, possible Hemostasis changes.

Question 5

What is the treatment for VWD

Answer 5

• DDAVP
o Major side effect is hyponatremia