Third test Flashcards

1
Q

Acebutolol

A

B1 selective blocker
Partial Agonist (ISA)
Membrane stabilizing
low lipid solubility ?

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2
Q

Atenolol

A

B1 selective blocker
Not Partial agonist
Not membrane stabilizing
low Lipid soluble

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3
Q

Esmolol

A
B1 selective blocker
Not partial Agonist
Not Membrane stabilizing
Low Lipid Soluble
rapid action, rapid broken down by plasma esterase's
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4
Q

Metoprolol

A

B1 Selective blocker
Not partial Agonist
Membrane Stabilizing ?
Moderate Lipid Soluble

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5
Q

Nadolol

A
B1 and B2 blocker
Not partial agonist
no membrane stabilize
Low Lipid solubility
longest activity
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6
Q

Pindolol

A
B1 and B2 selective blocker
Partial Agonist (ISA), Membrane stabilizer ?
 ISA doesn't affect B2 mediated inhibition, actually enhances the relax adding to anti HTN effect
Moderate Lipid soluble
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7
Q

Propranolol

A

B1 and B2 selective blocker
no partial agonist
Membrane stabilize
High Lipid soluble

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8
Q

Timolol

A
B1 and B2 selective blocker
no partial agonist
no membrane stabilize
Moderate lipid solubility
used in glaucoma treatment
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9
Q

PheNoxybenzamine

A

Non- selective a1 a2 blocker
non- competitive inhibition via Irreversable inactivation of receptor
used to prevent severe HTN episodes in pheo patients prior to surgery
better than selective a1 info b/c blocked the extra synaptic a2 in HTN
SE: inhibit some non adrenergic receptors (H, 5HT, Ach)
SE: miosis, drowsiness, vomit lethary (enters CNS), shock/circ fail

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10
Q

PheNtolamine

A

short acting a1 and a2 reversible blocker
Pheo diagnostic testing, and during surgery
used to reverse systemic vasoconstrict and related HTN from non specific a-agonist like NE
limit local dermal tissue necrosis after a-agonist injection
dental anesthetic reversal
SE: Nausea,vomit, diarrhea, Increase GI motility(bad for ulcers), may interact with non a receptors

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11
Q

PrazoSin

A

Prototype selective a1 blocker- competitive
long term treatment of mild to moderate HTN
Relax smooth muscle of bladder neck, relieve urinary obstruction
raynauds treatment
SE:First dose phenomenon orthostatic HypoTN, Na H20 retention, reflex tachycardia, not as much as non selective

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12
Q

DoxazoSin

A

newer selective a1 blocker than prazosin
use and side effect just life Prasozin, but with longer half lives so better long term control of HTN and BPH
Relax smooth muscle of bladder neck, relieve urinary obstruction
raynauds treatment
SE:First dose phenomenon orthostatic HypoTN, Na H20 retention, reflex tachycardia, not as much as non selective

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13
Q

TerazoSin

A

newer selective a1 blocker than prazosin
use and side effect just life Prasozin, but with longer half lives so better long term control of HTN and BPH
Relax smooth muscle of bladder neck, relieve urinary obstruction
raynauds treatment
SE:First dose phenomenon orthostatic HypoTN, Na H20 retention, reflex tachycardia, not as much as non selective

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14
Q

TamsuloSin

A

Selective a1 subunit A blocker(a1A)
the main subtype found in the bladder neck and the prostate vs the a1 found systemically
good drug for BPH with less systemic side effects(decrease BP, orthostatic syncop)
can still cause abnormal ejaculation

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15
Q

SilodoSin

A

Selective a1 subunit A blocker(a1A)
the main subtype found in the bladder neck and the prostate vs the a1 found systemically
good drug for BPH with less systemic side effects ( decrease BP, orthostatic syncop)
can still cause abnormal ejaculation

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16
Q

AlfuzoSin

A

selective a1 blocker used in BPH treatment but not subtype specific like tamsulosin and silodosin
shows uroselectivity by accumulating in the prostatic tissue
doesn’t significantly influence vascular alpha receptors

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17
Q

Reserpine

A

Peripherally acting Sympathetic neuronal blocker

decreases the availability of NE to its receptor by inhibiting NE and DA storage in vessicles

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18
Q

Guanethidine

A

Peripherally acting Sympathetic neuronal blocker

decreases the availability of NE to its receptor by inhibiting NE and DA storage in vessicles and preventing release

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19
Q

Centrally acting Sympathetic neuronal blockers

A

Methyldopa
Clonidine
Guanabenz
Guanfacine

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20
Q

methyl dopa

A

centrally acting adrenergic neuronal inhibitor
converted to alpha-methylNE thats acts as an a2 agonist in central vasomotor centers to dampen simp outflow leading to decreased renin, decreased HR and CO(or not), and most important decreased arterial peripherial pressure
SE:peripheral fluid retention, centrally mediated dry mouth, certain autoimmune disorders, hemolytic anemia, abnormal liver function

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21
Q

Clonidine

A

centrally acting adrenergic neuronal inhibitor
not a prodrug
similar action to methyl dopa as a a2 agonist to dampen simp outflow
lower doses than methyldopa, in patch form
no autoimmune SE, rebound HTN
treatment of: adhd, meno hot flash, stress disorder, nicotine and ethos withdrawal

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22
Q

Guanabenz

A

centrally acting adrenergic neuronal inhibitor
similar to clonidine binds a2 receptors to dampen symp outflow and treatment of HTN
shown to lower cholesterol,
less reactive fluid retention so no diuretic needed to preserve HTN effect

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23
Q

Guanfacine

A

centrally acting adrenergic neuronal inhibitor
similar to clonidine in action and HTN effect
less sedation, less likely to cause withdrawal syndrome
recently made into intuniv for ADHD

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24
Q

Nicotine

A

Ganglionic Stimulant

finish this card

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25
Q

Mecamylamine

A

Ganglionic BLocking Agent

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26
Q

Epinephrine

A

Adrenergic Bronchodilator

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27
Q

Isoproterenol

A

Adrenergic Bronchodilator

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28
Q

Metaproterenol

A

Adrenergic Bronchodilator

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29
Q

ALbuterol

A

Adrenergic Bronchodilator

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30
Q

Salmeterol

A

Adrenergic Bronchodilator

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31
Q

Terbutaline

A

Adrenergic Bronchodilator

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32
Q

Pirbuterol

A

Adrenergic Bronchodilator

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33
Q

Theophylline

A

Methylxanthine Bronchodilator

34
Q

aminophylline

A

methylxantine Bronchodilator

35
Q

Beclomethasone

A

corticosteroid

36
Q

flunisolide

A

corticosteroid

37
Q

triamconolone

A

corticosteroid

38
Q

budesonide

A

corticosteroid

39
Q

prednisone

A

corticosteroid oral

40
Q

mimetasone

A

corticosteroid

41
Q

methylprednisolone

A

corticosteroid

42
Q

Cromolyn Na

A

Mast cell stabilizer

43
Q

monteleukast

A

Leukotriene Modulators

44
Q

zafirleukast

A

Leukotriene Modulators

45
Q

Zileuton

A

Leukotriene Modulators

46
Q

Ipratropium

A

Antimuscarinic

47
Q

tiotropium

A

Antimuscarinic

48
Q

aclidinium

A

Antimuscarinic

49
Q

Omalizumab

A

Immuomodulator Anti IgE

50
Q

Diphenhydramine

A

H1 histamine antagonist

51
Q

Fexofenadine

A

H1 histamine antagonist

52
Q

Cetiriziine

A

H1 histamine antagonist

53
Q

Lorantidine

A

H1 histamine antagonist

54
Q

Hydrochlorothiazide

A

Diuretic

distal tubule

55
Q

Furosemide

A

diuretic

Loop diuretic

56
Q

Spironolactone

A

Diuretic

K+ sparing diuretic

57
Q

lebetalol

A

a1/B blocker and NO releasing B1 blocker

58
Q

Nebivolol

A

a1/B blocker and NO releasing B1 blocker

59
Q

Verapamil

A

Ca channel blocker

60
Q

Nifedipine

A

Ca channel blocker

61
Q

Castopril

A

ACE inhibitor

also any drug ending in “PRIL”

62
Q

Losartan

A

Angiotensin II receptor blocker

Also and drug ending in”sartan”

63
Q

Aliskiren

A

Renin inhibitor

inhibits renin after its release

64
Q

Lovastatin

A

HMG-CoA reductase inhibitors

other statin drugs

65
Q

Nitroglycerin

A

Nitrate

used to treat angina

66
Q

Levothryoxine

A

used to treat Hypothyroid

synthetic T4

67
Q

131 I

A

used to treat Hyper thyroid
beta particle emitter, kills tissue
contraindicated in nursing mothers

68
Q

Propylthiouracil

A

used to treat Hyper thyroid, a thionamide
inhibit thyroid hormone synthesis by inhibiting iodination rxn and coupling of idolatyrosin
does not inhibit pre formed T3, T4 release
SE: mild rash, hepatotoxicity, agranulocytosis, vasculitis and rare drug induced lupus
blocks t4 conversion to t3 in periphery, safe for pregnant pts

69
Q

methimazole

A

used to treat Hyper thyroid, a thionamide
inhibit thyroid hormone synthesis by inhibiting iodination rxn and coupling of idolatyrosin
does not inhibit pre formed T3, T4 release
SE: mild rash, hepatotoxicity, agranulocytosis, vasculitis and rare drug induced lupus

70
Q

KI

A

lugol’s solution
used to treat Hyper thyroid
inhibits release of pre-formed/ stored hormone

71
Q

alendronate

A

used to treat osteoporosis

used to treat Paget’s disease

72
Q

Risedronate

A

used to treat osteoporosis

73
Q

ibandronate

A

used to treat osteoporosis

74
Q

zoledronic acid

A

used to treat osteoporosis
used to treat Paget’s disease
used to treat hypercalcemia

75
Q

raloxifene

A

used to treat osteoporosis

76
Q

Calcitriol

A

used to treat osteoporosis

77
Q

Calcitonin

A

used to treat Paget’s disease

used to treat hypercalcemia

78
Q

Pamidronate

A

used to treat hypercalcemia

79
Q

phenyl ephrine and midodrine

A

selective a1 agonist
IV- raises diastolic and mean BP with more reflex bradycardia than NE
used in neurogenic shock to maintain diastolic and mean BP, or during spinal anesthesia
treat hemorrhoids and nasal conjestion

80
Q

cocaine

A

inhibits NE reuptake at the synapse

good local anesthetic, exerts it own local vasoconstrictor action at site in injection

81
Q

Pseudo ephedrine

A

stimulate NE release from nerve endings without sympathetic input
treat nasal and bronchial congestion