THICKNESS TEST Flashcards
Tab thickness varies with changes in die fill, with particle size distribution and packing of the particle mix being compressed and with tablet weight.
Constant compressive load
Thickness varies with variations in compressive load
Constant die fill
Thickness can be vary with no change in weight due to
a. Difference in the density of the granulation
b. The pressure applied to the tablet
3. The speed of the tablet compression
USP Specification for thickness
+/- 5% variation
Give 3 equipment used on thickness test
Vernier Caliper
Thickness gauge
Micrometer Caliper
Instrument that measures the thickness or the diameter of
relatively small parts;
It produces finer results than a vernier caliper.
Micrometer Caliper
Part that stops the finely threaded screw when the pressure on the object being measured is sufficient.
Rachet Knob
Horseshoe-shaped part that supports the anvil and a graduated device from which the measurement is read.
Frame
Cylindrical part that is attached to the frame of the micrometer to support the object to be measured; the object is placed between the anvil and the spindle.
Anvil
Screw driven by the ratchet knob that moves the spindle against the object to be measured.
Finely threaded screw
Graduated cylindrical part that is activated by the finely
threaded screw and measures the thickness with precision.
Thimble
Cylindrical end of the finely threaded screw
Spindle
Ring-shaped part that locks the finely threaded screw in its final position to preserve the measurement obtained.
Lock nut
The Vernier scale consists of a measurement of 49 mm marked in millimeters. It is used to
determine the second decimal number in
millimeter reading.
Vernier Scale
This is used to measure the internal diameter of objects.
Ears/Upper Jaw
This is used to measure the external diameter of a tube or container.
Lower Jaw
This is used to determine the main length of the materials
Main scale
This gauges the least count, the smallest increments in the readings of a
measuring instrument.
Tail
Enumerate the 4 parts of Vernier scale
- Ears/Upper Jaw
- Lower Jaw
- Main Scale
- Tail
Enumerate the 7 parts of Micrometer Caliper
- Rachet Knob
- Frame
- Anvil
- Finely threaded screw
- Thimble
- Spindle
- Lock nut
Weight of the tablet effected by:
- The physical dimensions of the tablet
- Density of the materials and their proportion
The size and shape of the tablet can be influence:
- Choice of tablet machine
- P.S for granulation
- Production lot sizes
- Packaging operations
- Cost to produce the tablet
