THIAZIDE DIURETIC

Question 1

THIAZIDE DIURETIC - examples

Answer 1

Chlorthalidone
Indapamide
Bendroflumethiazide

Question 2

THIAZIDE DIURETIC - indications

Answer 2

Hypertension

Question 3

THIAZIDE DIURETIC - when is it best to take?

Answer 3

Best to take in the morning so diuretic effect occurs throughout the day - rather than taking at night and having disrupted sleep

Question 4

THIAZIDE DIURETIC - MOA

Answer 4

Inhibit Na+/Cl- cotransporter in the DCT of the nephron = prevents reabsorption of Na+/H20 = diuresis = decreases total blood volume = decreases CO = decreases BP

Long term effects = vasodilatation (not fully understood)

Question 5

THIAZIDE DIURETIC - adverse effects

THHIC

Answer 5

Hyponatraemia

Hypokalaemia

Cardiac arrhythmia

Impotence in men

Question 6

THIAZIDE DIURETIC - interactions

Answer 6

NSAIDs (other than low-dose aspirin) may lower effectiveness of thiazide

Avoid use with loop diuretics

Question 7

THIAZIDE DIURETIC - contraindications

Answer 7

Avoid use in patients with hypokalaemia and hyponatraemia

Question 8

THIAZIDE DIURETIC - patient communication - how would you describe to the patient what this drug does?

Answer 8

Explain to patients that you are giving them a “water tablet” for their high blood pressure (if applicable and with their leg swelling) - it will basically work by making you urinate more which will in turn decrease the amount of fluid circulating in your body and decrease your blood pressure

Question 9

DIURETICS - which diuretic is best suited for the treatment of chronic heart failure?

A- Indapamide
OR
B - Furosemide

Answer 9

Furosemide - loop diuretic

Question 10

DIURETICS - which diuretic is best suited for hypertension treatment?

A- indapamide
OR
B - furosemide

Answer 10

Indapamide - thiazide diuretic

Question 11

Thiazide diuretic - caution

Answer 11

Caution in patients with gout - may trigger acute attacks