Thiamin

Question 1

What occured in 1696 BC (history of thiamin)

Answer 1

Beriberi was described in chinese medical books

Question 2

What did takaki discover? (Japanese navy) and in what year?

Answer 2

Beriberi was assosiated with food

1884

Question 3

What did heijkman discover? And in what year?

Answer 3

Polyneuritis in hens was similar to the beriberi in humans

1890

Question 4

What did hopkins discover? And in what year?

Answer 4

1906 . Diet consuming only protein salt fat and carb is not enough to support growth
Accessory food factors (vitamins now) are required

Question 5

Who discovered the theory of vital amines and in what year? What is it

Answer 5

1911 
Funk 
There are substances essential to life 
He isolated a substance from fice hulks that was providing nutritional benefit and called it amine 
Vitae amine = vitamin

Question 6

What did jansen and donath do ? And in what year?

Answer 6

They isolated and crystallized vitamin B1

1926

Question 7

What did willams and cline discover and in what year?

Answer 7

They discovered the structure of vitamin and its function

1934

Question 8

What did lohman and schuster discover and in what year?

Answer 8

1937

Tpp as coactive enzyme

Question 9

Is vitamin b1 highly water soluble?

Answer 9

Yes

Question 10

Is vitamin b1 heat stable?

Answer 10

No

Question 11

In what form is vitamin b1 heat stable? And at what temp?

Answer 11

Powdered form , 100 C

Question 12

Is vitamin B1 stable at an acidic pH / low pH

Answer 12

Yes

Question 13

Is vitamin b1 destroyed at pH >8?

Answer 13

Yes

Question 14

How can vitamin B1 also be destroyed? (2 stuff)

Answer 14

Chlorine

U v rays, x rays, sulfite

Question 15

What happens to vitamin B1 in acidic and aqeous solution?

Answer 15

Becomes stable to heat and oxidation

Question 16

What is the structure of active vitamin B1?

Answer 16

Pyrimidine ring
Thiazole moiety
Linked by methylene (ch2)
2 phosphate groups

Question 17

What are other names for vitamin b1 (active)? (3 stuff)

Answer 17

Thiamin pyrophosphate
Thiamin diphosphate
Cocarboxylase

Question 18

What are other names for vitamin B1?

Answer 18

Aneurine
Thiamin
Vitamin F

Question 19

Can humans link thiazole to pyrimidine ?

Answer 19

No

Question 20

What is TDP considered?

Answer 20

Active coenzyme

Question 21

What is the molar mass of thiamin?

Answer 21

Mw = 266.4

Question 22

What is the molar mass of thiamin HCl and what is it used for?

Answer 22

MW= 337.3

Used as a supplement

Question 23

What is the factor used to multiply ng/mL to get nmol/L

Answer 23

2.69

Question 24

What is the factor used to multiply mol/L to get ng/L?

Answer 24

0.3373

Question 25

Does thiamin contain sulfur? If yes where?

Answer 25

Yes

In thiazole

Question 26

Does thiamin contain an amine group?

Answer 26

Yes

Question 27

How is vit b1 precipitated? (4 s)

Answer 27

Iron
Various alkaloids
Ammonium citrate
Tannins

Question 28

How Much vitamin B1 is in yeast

Answer 28

6–24 mg per 100 g

Question 29

How much vitamin B1 is in pork

Answer 29

0.72–1.04 mg per 100 g



Question 30

How much vitamin B1 is in legumes

Answer 30

0.53–1 mg per 100 g



Question 31

Is the content of vitamin B1 high In whole or enriched grains 

Answer 31

Yes

Question 32

Name 4 analogs of thiamin

Answer 32

Oxythiamine
Pyrithiamine
Amprolium

2-methylthiamin?

Question 33

Thiaminase I
Action
Sources
Heat labile or stable

Answer 33

Exchange of thiazole ring
Changes structure of thiamin
Found in fresh water fish, shellfish, ferna, sea fish and certain microorganisms
Heat labile

Question 34

Thiaminase II
Action
Sources
Heat labile or stable

Answer 34

Hydrolysis, reduces biological activity of thiamin
Some microorganisms
Heat labile

Question 35

What are the heat stable antithiamin factors

Answer 35

Haemin
Polyphenols
Ruminants
Flavonoids