Thermoregulation Flashcards

1
Q

Thermoregulation

A

Process of maintaining core body temperature at a near constant value

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Normothermia

A

36.2-37.6 de reefs Celsius

97-100 F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hypothermia

A

Less than 36.2 C

Mild-34-36C (93.2-96.8F)
Moderate- 30-34C (86-93F)
Severe- less than 30C (less than 86F)

Accidental- left out in cold, fall into river or lake, not wearing enough clothes

Therapeutic- decreased perfusion with MI or injury; kept in mild hypothermia to slow down body processes because they use less oxygen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hyperthermia

A

Greater than 37.6 C

Body temp rises with unchanged hypothalamic set point

Natural ability to get rid of heat is impaired

Environment can be too hot

Genetic- malignant hyperthermia

Drugs can cause- narcotics, anything that increases metabolic rate (e.g., amphetamines), some antibiotics, antihistamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hyperpyrexia

A

Extremely high temperature greater than 41.5 C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hypothalamus

A

Controls physiological adjustments

Uses the negative feedback loop to help regulate temperature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fever

A

Increase in hypothalamic set point where the negative feedback loop works to cool the body down with a higher temperature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Infants and toddlers

A

Increased risk for hypothermia

Lack ability to conserve heat and immature body processes

Have large body surface area compared to mass which is also why they dehydrate faster

Decreased subcutaneous fat which acts as an insulator

Unable to correct changes/dependent on caregivers- cannot put on more clothes or take them off

Rule of thumb: have one more layer of clothing than what adults need. EX: if an adult has a sweatshirt on, the infant should have a t-shirt and a sweatshirt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Elderly

A

Risk for hyperthermia

Sweat glands decrease- decreased ability to perspire and use evaporation to cool selves

Reduced circulation can cause peripheral problems

Decreased vasoconstrictive response to cold- they can get cold faster as they continue to dilate esp. if they are on meds that cause vasodilation

Reduced shivering response as the muscles don’t respond as well and are cold more often

Slower metabolic rate- cold more often

Reduced perception of heat and cold so they may not recognize when they are cold or hot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Other populations at risk

A

Low socioeconomic status- if they cannot afford heat or cooling systems, warm clothing, etc.

Homeless- no protection from the elements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Risk factor: cognition

A

Dementia may cause inability to recognize if it’s too hot or too cold. They may wander out into the elements without wearing proper clothing.

Substance abuse- alcoholics who are drunk may not notice the changes from the elements.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Risk factor: health condition

A

CHF & DM patients have poor perfusion and a decreased ability to vasoconstrict or vasodilate, peripheral neuropathies where they are unable to feel the hot or cold as much

Traumatic brain injury- any injury to the hypothalamus can be chronically hot or cold

Poor nutritional status- if not maintaining glucose levels, can cause problems with heat or cold if glucose is not being used to cause shivering, etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Risk factor: genetics

A

Malignant hyperthermia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Risk factor: recreational or occupational exposure

A

Skiing or working in the cold, construction workers, running, exercising in the heat, etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How we gain heat

A

BMR

Muscular activity

Hormones (e.g., thyroid hormone)

Dietary-induced thermogenesis (we eat a lot, we get warm)

Postural changes (can gain heat by curling up into a ball which provides less surface area to lose heat)

Environment (external heat)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How we lose heat

A

Radiation

Conduction

Convection

Evaporation

Muscles

Respirations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Heat production and conservation

A

Produced through metabolic activity:
Ingestion and metabolism of food will create heat and keep us warm.
BMR- the higher the BMR, the warmer we typically are.
Amount of heat is dependent on amount of food, physical activity, and hormone levels. With physical activity, the more active we are, the more we create heat and normal hormone levels.

Chemical thermogenesis:
Epinephrine will make us warm and great more heat.

Conservation through peripheral vasoconstriction:
Heat is conserved through peripheral vasoconstriction; if I take my blood and stick it centrally in my body, I have less available at the surface and less available to lose heat. This makes vasoconstriction a good heat conserved.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Radiation heat loss

A

Electromagnetic waves that emit heat from the skin surface to the air

More skin exposed, the more heat lost

Vasoconstriction or dilation can help hold onto or lose heat by making blood readily available or pulling blood centrally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Conduction heat loss

A

Heat travels through something solid with direct contact

EX: our body sits on something cool, looses heat to cooler surface. This cools the body down. This is why we put a warming blanket down for older adults or put infants in a warmer- so they do not lose heat to the surface of the bed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Convection heat loss

A

Loss of heat by air currents

The flow of heat from the body surface to cooler surrounding air. Eliminate drafts such as windows or AC to reduce heat loss by convection

Naturally happens with the more exposed skin

Warm air (from skin) rises, will go away from our skin and cool air will enter and replace the warm air. This happens even without drafts. If there are drafts, heat loss by convection increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Vasodilation heat loss

A

More convection can happen with this

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Evaporation heat loss

A

Perspiration creates energy

When a liquid is converted into gas, it requires energy. It will take energy heat from the skin to cause evaporation. It produces cooling. We can promote that by using convection which increases evaporation rates.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Muscle activity heat loss

A

When the body itself is too hot, muscle tone will decrease

This decreases BMR and decreases our heat

This explains when it’s too hot, you feel tired and don’t feel like moving. Moving takes effort because the body is decreasing muscle tone.

24
Q

Respiration heat loss

A

With ambient, cool air, this air is breathed in, the body warms it, used it for energy, then exhales the warm air which can cool our body

This only works if the ambient air is cooler than our body temperature

25
Q

Temperature control

A

Hypothalamus and the negative feedback loop

Heat production and conservation with endocrine and sympathetic action: hypothalamic pituitary thyroid

26
Q

Heat production with hypothermia

A

When thermoreceptors in the skin, spinal cord, and abdominal organs detect that our temperature is too low, heat production occurs

The hypothyroid stimulating hormone releasing hormone- the TSH, rh, and the hypothalamus sends the message to the pituitary which releases thyroid stimulating hormones which tells the thyroid gland to make T4 which goes to the kidney adrenal medulla to produce epinephrine. Epinephrine increases BMR starting with glycolysis (increase our glucose). This provides more energy to muscles to increase muscle tone, causing vasoconstriction to conserve heat, and increases muscle tone and shivering

27
Q

Sympathetic nervous system: Cholinergic neural changes

A

Sweat glands

Heat loss by evaporation

28
Q

Sympathetic nervous system: Alpha adrenergic neural changes

A

Blood vessels

Internal flow of heat from core to skin

29
Q

Sympathetic nervous system: Beta adrenergic neural changes

A

Brown fat

Non-shivering thermogenesis in infants

30
Q

Somatic nervous system: cholinergic neural changes

A

Skeletal muscle

Heat production by shivering

31
Q

Hyperthermia consequences

A

Sweating leads to dehydration and sodium loss

Vasodilation: hypotension, tachycardia, decreased CO, coagulation due to thicker/viscous blood, CV collapse

Cerebral edema: CNS degeneration starts with confusion leading to seizures and stupor and leading to death

Renal necrosis r/t lack of perfusion

32
Q

Hyperthermia exam

A

Vasodilation: flushed, red skin

Diaphoresis: clammy, sweating

Dehydration: dry skin, dry mucous membranes, decreased urine output, increased urine specific gravity, electrolyte imbalance (low sodium, high potassium- hemoconcentrated from sodium loss)

Neuro: confusion leading to stupor, coma, and death

33
Q

Hyperthermia interventions

A

Remove clothing (cotton breathes better than polyester or synthetics)

Monitor CO with vasodilation and tachycardia

Hydrate with isotonic solution

Cool packs where arteries are closest to the surface allowing for more central cooling. Good locations: axilla, in the groin on top of the femoral arteries, behind the knees, sides of the neck. Don’t want too cold that it’s causing shivering because this will increase their temperature.

Gastric or colonic lavage in severe cases- run cold water through the stomach and through the rectum

34
Q

When fever occurs

A

When microorganisms invade:
endogenous pyrogens are released into the bloodstream; these substances travel to the hypothalamus where they trigger the production and release of prostaglandins; prostaglandins initiate a fever response

Fever is typically a reaction to a microorganism. It is a therapeutic method by the body to attempt to kill microorganisms.

Leaving a temperature may help kill a virus faster.

35
Q

Fever risks

A

Diminished immune response

Very young, very old

Adolescents who practice risky behavior resulting in infections, neurological trauma, alcohol/drug abusers

Children in daycare

The under or unvaccinated

36
Q

Sustained fever

A

Constant above 38C (100.4 F) with little fluctuation

37
Q

Intermittent fever

A

Fever spikes interspersed with usual temperature levels

38
Q

Remittent fever

A

Fever spikes and falls without a return to normal temperature levels

Go up and down without reaching normal levels. EX: 102, then 100, then 103, etc.

39
Q

Relapsing fever

A

Periods of febrile episodes and periods with acceptable temperature values

40
Q

Fever treatment

A

Antipyretics- NSAIDs and Tylenol are most common. NSAIDs are best to cover inflammation and fever.

No aspirin for children and adolescents due to risk of Reye’s syndrome which causes a pneumonia production which can cause permanent brain damage leading to death.

Take off clothing, ice packs (be careful they do not shiver)

41
Q

Febrile seizures

A

Usually occur in children from a rapid rise in temperature above 39C (102F) in association with acute viral or bacterial illness. Not about how high it goes but how fast it gets there.

No intracranial infection or other defined cause is found. Still, assess for neuro S/S indicative of meningitis or encephalitis. Immature neurology puts kids at risk.

Usually between 3 months to 5 years old. They usually will grow out of it by the time they’re 5-6 years old.

Often have family history

Children who have had one are 30-50% more likely to have another. The lower convulsive threshold of infants may explain this type of seizure.

Teach parents to monitor seizures ans give Tylenol or NSAIDs to keep temperature down

42
Q

Tests for pediatric fevers

A

Under 29 days, will perform LP on febrile patients due to the risk of meningitis or encephalitis that could have been passed from mom during birth.

Blood tests: CBC with differential and blood culture

Urine test: urinalysis and culture

Stool tests: culture and fecal WBC count if diarrhea present

Chest radiography

43
Q

Malignant hyperthermia

A

Inherited muscle disorder

Reaction to general anesthesia and succinylcholine

Massive amounts of muscle contraction cause a high serum calcium and potassium

Sustained muscle contraction (rigidity) increases our BMR. Temperatures can go up into the 40-41C range very quickly

Observe for a rapid rise in temperature, tachycardia, hypertension, and increased muscle contractions

Quick action is necessary or the patient will die

Treat: terminate inhaled gas, IV therapy, quick cooling with ice, Dantrolene IV is the only effective drug

44
Q

Treating malignant hyperthermia

A

Stop all anesthesia

Dantrolene 2-3mg/kg is the only drug for this. It’s a major muscle relaxant which stops muscle contractions and hyperthermia

Access acidosis: hang bicarb quickly

Insulin for hyperkalemia

Cooling blanket/saline infusion/ ice/ lavage

Foley to get good urine output to monitor for kidney ischemia

Treat dyrhythmias

Look at family history: may use other forms of anesthesia if this condition is possible from family history. If S/S of it occur, stop all anesthesia

Will try to book their surgery first thing in the morning so there isn’t any residual anesthesia gases in the machines

45
Q

Hypothermia consequences

A

Dependent on severity and duration

Tissue ischemia- skin is low tolerant to not being perfumed well; fingers, toes,smaller appendages, and nose are common areas for frostbite

As vasoconstriction fails to warm the body, vasodilation occurs. This is more dangerous because the patient feels warm and may even take clothes off

Temperature under 28C- ice crystals form in our cells and begin bursting cells causing cellular death, decreased perfusion, ischemia, and necrosis

46
Q

Hypothermia exam

A

Vasoconstriction: cool, pale skin

Muscle rigidity and shivering as the body increases BMR to make heat (muscles feel tight)

Cognition decreased because of colder, slower perfusion of blood to the brain: fatigue, lethargy, confusion

Dysrhythmias because heart isn’t being perfumed as well

Slower metabolic rate and poor perfusion: decreased urine output a d CV collapse

47
Q

Hypothermia interventions

A

Passive external warming: dry clothing, warm drinks, exercise; heating pads (careful not to cause burns); warm bath

Active core rewarding: warm fluid IV, peritoneal and gastric lavage, inhaled warm oxygen

Don’t warm too quickly. Fast warming can cause ice crystals to burst more cells. Cold: put them in tap water that is not too hot. If it’s stinging, it’s too warm. Slowly reward to avoid ischemia

48
Q

Hyperthyroid S/S (SPEED UP)

A

Skin- diaphoresis, moist, sweaty, thinning hair

CV- tachycardia, HTN

Respiratory- tachypnea

GI- wt. loss/diarrhea , hunger r/t increased BMR

Neuro- irritability, exopthalamous (bulging eyes), blurry vision

Hyper metabolism- fever

Other- manic, goiter

Labs- decreased TSH, production of too much thyroid hormones T3 and T4

Large amount of T3 & T4 tell the pituitary not to make thyroid stimulating hormone (TSH), making TSH low because T3 and T4 are high. If there is a hypothalamus problem where it is overstimulating the thyroid stimulating hormone releasing hormone, then T3 and T4 will typically be high.

Goiter- big neck from thyroid overproducing

49
Q

Hyperthyroid treatment

A

Meds inhibit new production by blocking iodine binding sites in the thyroid: Propythiouricil (PTU)- look at concerns with liver damage; Methimazole can cause birth defects

Thyroid has a very high affinity for iodine

Radioactive iodine- take a radioactive solution that tags onto iodine. As the body ingests the iodine, the body uptakes it and the radiation destroys the thyroid tissue. They are radioactive after and should not be around babies who are more risk for radiation

Thyroidectomy- may do partial or full

Risks for radioactive iodine and thyroidectomy is hypoglycemia as we are destroying thyroid tissue

50
Q

Thyroid storm

A

Excessive hormone release. Can be an essential problem- pituitary tissue. Can be a problem with the thyroid tissue itself

Fever. Tachycardia, HTN

Anxious to confused to psychosis

May lead to death

Treat S/S of hyper metabolism: need massive amount of fluid because of diuresis and diarrhea; need antipyretics for the high fever; beta blockers and calcium channel blockers to treat tachycardia; labetalol to treat HTN

Treat symptomatically until thyroid can be under control

PTU is typically done to start blocking the thyroid production

51
Q

Hypothyroid S/S (SLOW DOWN)

A

Skin- dry, brittle, hair loss

CV- bradycardia, hypotension

Metabolic- wt. gain, cold r/t inability to produce heat

Psych- depression

GI- constipation, anorexia

Neuro- lethargy, paresthesias

Other- edema, bradypnea, myxedema (head and neck; can cause airway problems)

Labs- increase TSH; decreased T3 and T4

52
Q

Myxedema- untreated hypothyroid

A

Decreased CO from poor heart muscle contraction increases edema

Hypothermia (30-32C)

Treatment: warming mattress, IV levothyroxine (looking at T3), IV glucose (metabolism is lower), corticosteroids (increase epinephrine to heat the body up)

53
Q

Measuring temperature

A

Oral- most common; wait at least half an hour since smoking, eating, or drinking

Axillary- preferred site in infants, developmentally delayed, or cognitively impaired; ensure skin-to-skin contact in both sides. May be inaccurate with hypothermia; usually 0.5C (0.9F) lower than oral

Rectal- stick in by an inch; don’t do on immunocompromised, bleeding disorder, neonates, or reveal surgery; usually 0.5C (0.9F) higher than oral

Tympanic- high degree of user errors based on cooperation, exact angle of insertion, etc.

Temporal artery- high degree of user error. It needs to catch the temporal artery in two different places: across and down the forehead

In the ICU, temperature-probes can be built into the foley or ET tube to measure core samples

54
Q

Neonatal physiology

A

Predisposes to poor thermal control

Wet skin at birth and high surface area to body ratio- lost heat via skin surface

Immature hypothalamus- does not react as well or as quickly to temperatures that are too hot or too cold

At term baby has more brown fat than the adult which is is used to create heat. Pre-term babies are at high risk for hypothermia because they have not yet developed brown fat. They use this brown fat for non-shivering thermogenesis. Term babies lack subcutaneous fat which acts as an insulator so they are also at risk for hypothermia, but not as severe as the preterm baby

Drying and wrapping or skin to skin contact with a hat is required for temperature control

55
Q

Effects of cold

A

Decreased surfactant efficiency: the cooler they are, the less surfactant works; they are then unable to open their airways and breathe effectively

Increased oxygen consumption- using more oxygen to stay warm

Respiratory distress

Increased utilization of calories as BMR increases because they are trying to maintain heat

Reserves- hypoglycemia

Increased postnatal weight loss

56
Q

Thermal care

A

Monitor temperature and observe for instability

Skin to skin contact, cover/wrap, hats to keep baby warm and prevent heat loss

Plastic wrapping for preterm neonates in delivery suite and then humidification to decrease loss of perspiration

Maintain the neutral thermal environment