Therapy

Question 1

Which RP is used to battle against Hepatic Cancer?
(a) Ra-223 Dichloride (Xofigo)
(b) Y-90 Microspheres (TheraSphere)
(c) Sr-89 Chloride
(d) Y-90 Ibritumomab Tiuxetan (Zevalin)

Answer 1

(b) Y-90 Microspheres (Therasphere)
-due to the glass microspheres, they are able to emit small radioactive spheres to selectively radiate and kill hepatic tumor.

Question 2

What is the half life of Y-90?
(a) 8 days
(b) 11 days
(c) 46 hr
(d) 64 hr

Answer 2

(d) 64 hr
Beta Emitter with 927 keV.

Question 3

Dose to Liver for Hepatic Cancer Therapy with Y-90 Microspheres is 80-150 Gy (8,000-15,000 rad).
(a)True
(b)False

Answer 3

(a) True

Question 4

What Prep occurs before Y-90 Microsphere administration?
(a) Hepatic Arterial Cath with Tc99m-MAA
(b) No Prep
(c) Recent Blood count
(d) Whole-Body scan with In-111 Zevalin.

Answer 4

(a) Hepatic Arterial Cath with Tc99m-MAA.
Y-90 Microspheres can get shunted to lungs. 2-4 mCi Tc99m-MAA through a Hepatic Arterial Cath helps determine the extent of A-V Shunting AND confirm the absence of gastric/duodenal flow (absence means no shunting which means less unwanted radiation to other organs). If Lung Shunt is >20% = NO THERAPY.