Therapy Flashcards
Which RP is used to battle against Hepatic Cancer?
(a) Ra-223 Dichloride (Xofigo)
(b) Y-90 Microspheres (TheraSphere)
(c) Sr-89 Chloride
(d) Y-90 Ibritumomab Tiuxetan (Zevalin)
(b) Y-90 Microspheres (Therasphere)
-due to the glass microspheres, they are able to emit small radioactive spheres to selectively radiate and kill hepatic tumor.
What is the half life of Y-90?
(a) 8 days
(b) 11 days
(c) 46 hr
(d) 64 hr
(d) 64 hr
Beta Emitter with 927 keV.
Dose to Liver for Hepatic Cancer Therapy with Y-90 Microspheres is 80-150 Gy (8,000-15,000 rad).
(a)True
(b)False
(a) True
What Prep occurs before Y-90 Microsphere administration?
(a) Hepatic Arterial Cath with Tc99m-MAA
(b) No Prep
(c) Recent Blood count
(d) Whole-Body scan with In-111 Zevalin.
(a) Hepatic Arterial Cath with Tc99m-MAA.
Y-90 Microspheres can get shunted to lungs. 2-4 mCi Tc99m-MAA through a Hepatic Arterial Cath helps determine the extent of A-V Shunting AND confirm the absence of gastric/duodenal flow (absence means no shunting which means less unwanted radiation to other organs). If Lung Shunt is >20% = NO THERAPY.
What is the preferred therapeutic RP for Prostate Cancer?
(a) I-131 MIP
(b) Ga-68 PSMA
(c) F-18 PSMA
(d) Lu-177 PSMA
(d) Lu-177 PSMA is the preferred RP because of it’s lower renal dose.
For Prostate Cancer Patients, Lu-177 PSMA is given how often?
(a) given at 12 week intervals for 6 injections.
(b) given at 6-8 week intervals for 4 injections.
(c) given at 4-6 week intervals for 6 injections.
(d) given at 2-4 week intervals for 8 injections.
(b) given at 6-8 week intervals for 4 injections.
7.4 GBq (200 mCi) each injection IV.
Which of the following RP’s can be used for Neuroendocrine Tumors?
I. 123-I MIBG
II. 131-I MIBG
III. 177-Lu DOTATATE
IV. 131-I NP-59
(a) I and II.
(b) IV only.
(c) I, II, and III.
(d) All of the above.
(c) I, II, III.
123-I MIBG and 131-I MIBG images the adrenal medulla for pheochromocytomas, neuroblastomas, ganglioneuroblastomas, etc.
177-Lu DOTATATE is used for treatment of excess somatostatin receptors (SSTRs) on neuroendocrine tumors.
32-P Sodium Phosphate is used to treat:
(a) Polycythemia Vera
(b) Bone Pain
(c) Prostate Cancer
(d) a and b
(e) All of the above.
(d) Polycythemia Vera and Bone Pain.
Clear, 1-20 mCi.
What RP’s can be used to treat bone pain?
(a) 32-P Sodium Phosphate
(b) 89-Sr Strontium Chloride
(c) 153-Sm Lexidronam
(d) 177-Lu Lutathera
(e) a, b, d
(f) a, b, c
(g) all of the above.
(f)
32-P Sodium Phosphate, 89-Sr Strontium Chloride, and 153-Sm Lexidronam can be used as palliative treatment for bone pain from METs.
Ra-223 Dichoride (Xofigo) is used for?
(a) Palliative Treatment for Prostate Cancer.
(b) Resistant Prostate Cancer
(c) Non-Hodgkin Lymphoma.
(b) Resistant Prostate Cancer.
Ra-223 Dichloride is a calcium analog alpha emitter that targets increased bone metabolism. It is not palliative, instead it’s for prolonged survival.
50 kBq/kg at 4 week intervals for 6 injections.