Therapeutic Radiopharmaceuticals

Question 1

Sr89 chloride (Strontium)

Answer 1

Metastron

Question 2

Sm153 EDTMP

Samarium 153 ethylenediaminetetramethylene phosphonate

Answer 2

Lexidronam or Quartramet

Question 3

Y90 Ibritumomab tiuxetan

Answer 3

Zevalin

Question 4

Y90 microspheres / Sir-Spheres

Answer 4

TheraSphere

Question 5

Ra 223 Radium

Answer 5

Dichloride / Xofigo

injection is used to treat prostate cancer that no longer responds to hormonal or surgical treatment that lowers testosterone

Question 6

I-131 Iobenguane (MIBG)

Answer 6

Azedra

I 131 decays with beta and gamma emissions.

physical half-life of 8.021 days.

The principal beta emission has a mean energy of 191.6 keV
And
the principal gamma emission has energy of 364.5 keV

Note: Iobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine, typically used as a radiopharmaceutical. It acts as a blocking agent for adrenergic neurons

Question 7

Lu 177 lutetium dotatate

Answer 7

Lutathera

Question 8

I 125 seed

Answer 8

T1/2= 59.43 days

Think 60 days but 17 mins earlier

Note: RPTs are extremely rare tumors occurring in the retroperitoneum bounded anteriorly by the posterior parietal peritoneum and posteriorly by the transversalis fascia.

Note : Needles are inserted through the skin between the scrotum and the rectum. The needles are hollow, and allow the seeds to pass through the needle and be placed into the prostate at specific locations