Therapeutic Proteins

Question 1

FILGRASTIM

G-CSF

Answer 1

regulates the production of neutrophils within the bone marrow and affects neutrophil progenitor proliferation, differentiation and functional activation
also mobilizes hematopoietic stem cells, increasing their concentration in peripheral blood
led to the use of peripheral blood stem cells (PBSCs) rather than bone marrow stem cells for transplantation

cancer chemotherapy-induced neutropenia (esp. FILGRASTIM)
esp. during autologous stem cell transplantation following high-dose chemotherapy
objective is to prevent systemic infection (neutrophils are the 1st line of defence against infection)

allergic reactions
splenic rupture

Question 2

INTERLEUKIN 11

Answer 2

increase platelet production

atrial fibrillation
especially in the elderly or children
hypokalemia
doesn’t cause fever

Question 3

SAGRAMOSTIM

Answer 3

stimulates myelopoiesis generally, and neutrophils and monocytes specifically

capillary leak syndrome (peripheral edema, pleural or pericardial effusions) – some patients are extremely sensitive

Question 4

THROMBOPOIETIN

Answer 4

increase platelet production