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PHRM 836 Exam 2 > Therapeutic Drugs > Flashcards

Therapeutic Drugs Flashcards

1
Q

Tasonermin

A

TNF alpha itself used as an immunostimulant drug to treat certain cancers

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2
Q

Etanerecept

A

specifically binds to TNF alpha cytokine

approved to treat rheumatoid arthritis

fuses the TNFR2 to the Fc region of antibody

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3
Q

Siltuximab

A

antibody against IL-6

approved to treat Castleman’s disease

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4
Q

Tocilizumab

A

antibodies against the soluble IL-6R

treats rheumatoid arthritis

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5
Q

Sarilumab

A

antibody against the membrane bound IL-6R

treats rheumatoid arthritis

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6
Q

Anakinra

A

competitive inhibitor that blocks binding pockets on IL-1R

treat autoimmune disorders

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7
Q

Rilonacept

A

fusion between domains of IL-1R1/IL-1R3 to the IgG antibody

treat autoimmune disorders

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8
Q

Canakinumab

A

antibody that sequesters the IL-1B cytokine

treat autoimmune disorders

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9
Q

Secukinumab

A

antibody against IL-17A for psoriasis

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10
Q

5-flurouracil

A

converted to 5-fluoro-dUMP and inhibits TS

treats acute leukemia

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11
Q

Methotrexate

A

inhibits synthesis of 5,10-methlene tetrahydrofolate by inhibiting DHFR

treats acute leukemia

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12
Q

Mustard Gas & Cisplatin

A

alkylating agents

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13
Q

Gleevec / Dasatinib / Nilotinib

A

inhibit BCR-ABL and cure chronic myelogenous leukemia

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14
Q

Bortezomib

A

proteasome inhibitor

treats multiply myeloma and mantle cell lymphoma

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15
Q

PROTAC

A

E3 ligase-substrate inhibition

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PHRM 836 Exam 2 (2 decks)

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