Therapeutic Drug Monitoring

Question 1

Digoxin (Lanoxin)

Answer 1

Therapeutic 0.5-2 ng/mL
Toxic > 2.2 ng/mL

Digoxin toxicity—confusion, loss of appetite, nausea, vomiting, diarrhea, change in vision such as blurry or yellow vision, fatigue, fast or irregular heartbeat. Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue.

Question 2

Lithium (carbolith)

Answer 2

Therapeutic: 0.5-1.2 mEq/L
Toxic: > 1.5 mEq/L

Question 3

Valporic Acid (Depakote)

Answer 3

Therapeutic range: 50-125 mcg/mL

Toxic range: >125 mcg/mL

Question 4

Carbamazine (Tegretol)

Answer 4

Therapeutic range: 8-12 mcg/mL
Toxic range: > 12 mcg/mL

Question 5

Phenytoin (Dilantin)

Answer 5

Therapeutic range: 10-20 mcg/mL
Toxic range: > 30 mcg/mL

Question 6

Theophylline

Answer 6

Therapeutic range: 10-20 mcg/mL
Toxic range: >20 mcg/mL

Question 7

Lidocaine

Answer 7

Therapeutic: 1.5-5 mcg/mL
Toxic range: > 5 mcg/mL

Question 8

Acetaminophen

Answer 8

Therapeutic depends on use
Toxic range: > 250 mcg/mL

Question 9

Amikacin

Answer 9

Therapeutic range: 15-25 mcg/mL
Toxic range: > 25 mcg/mL

Question 10

Gentamicin

Answer 10

Therapeutic range: 5-10 mcg/mL
Toxic range: > 12 mcg/mL

Question 11

Vancomycin

Answer 11

Therapeutic range: 20-40 mcg/mL
Toxic range: > 40 mcg/mL