Therapeutic antibodies Flashcards
0
Q
What are three characteristics of monoclonal antibodies
A
High specificity, high affinity, long half life in vivo
1
Q
All therapeutic antibodies are what isotype?
A
IgG
2
Q
What type of antibodies are the following endings?
- umab
- momab
- ximab
- zumab
A
Human
Murine
Chimeric-fc all human, fab murine
Humanized- fc and most of fab human, small part of fab murine
3
Q
What are some characteristics of Mabs (size, type of molecule)
A
Large proteins, can’t be administered orally or they will be broken down in the stomach, aren’t filtered or eliminated by the kidney
4
Q
How are Mabs delivered
A
Must be administered parenterally ( not oral). 24-95% bioavailability with subq or IM.
