Theme I Flashcards
Per gram, how much energy does fat, carbohydrate, protein and alcohol give you
- Fat= 9kcal/ g
- carb= 4kcal
- protein= 4kcal
- alcohol= 7kcal
What is the estimated average requirement for energy nutrients and what it depends on
- Average intake needed for a healthy individual to maintain their energy balance (without losing or gaining weight)
- Depends on age, sex, weight, height, BMR, level of physical activity, growth
What is BMR and BMI and the mean values. How to calculate energy requirement for an individual
- BMI= weight (kg)/ height (m) squared
(18. 5-24.9) - BMR= basal metabolic index-=energy required for body to function (heart beating, breathing, brain function)
- women= 1400 calories daily
- men= 1800 calories
-requirement= BMR x physical activity level
Function of fat. What are the 3 types of fat and their sources
- Good source of energy, precursor of prostaglandins, reduces inflammation, required for absorption of fat-soluble vitamins (ADEK)
1. Saturated= no double bonds between Carbons in FA chain. Bad fat, increases LDL and decreases good HDL. Dairy products
2. Monosaturated= 1 double bond. VERY good because decreases cholesterol. Olives and nuts
3. Polysaturated= >1 double bond. Plant oils, fish oils. Good. Liquid at room temperature
Explain what the essential fatty acids are
- Linoleic (omega 6) and linolenic (omega 3) fatty acids - usually PUFA
- Plant and fish oils
- Form prostaglandins, reduce platelet aggregation, reduce thrombosis
Explain what cis and trans
- unsaturated.
1-Cis=H atoms are linked to the double bonded Cs on 1 side. Found in nature
2-Trans= H atoms are linked on one side
-in hydrogenated oils used by manufacturers to keep food fresher for longer. But it increases LDL and linked with CVD and colon cancer
What are used in a cholesterol low diet, to reduce cholesterol absorption
- Plant sterols and plant stanols: prevent cholesterol absorption, lower LDL. In fruits, veg, nuts, seeds, cereals
- Oat fibre: reduces absorption by binding to it
- soya protein in soya milk and tofu
What are carbohydrates. Food sources. How much energy you should get from it
- 50% of total energy should come from carbs
- Sugars, starches and oligosaccharides
- starch= potatoes, cereals, bread, pasta, rice
- sugars= confectionary, sugary drinks, table sugar, biscuits, preserves, cake etc.
- fibre= fruit, veg
What are monosaccharides, disaccharide and oligosaccharides. Give examples
- Monosaccharide= 1 sugar molecules (glucose, fructose, galactose)
- Disaccharides = 2 sugar molecules (sucrose, maltose, lactose)
- Oligosaccharide= 3+ sugar molecules. Not classed a sugars so manufacturers can be sneaky. They are polysaccharides. Don’t seem to cause caries
What are free sugars. Why they are bad
-Sugars that have been added to food, as well as sugars in syrups, honey, fresh fruit juice and fruit juice concentrates
(Sugars in fruit are not free sugars as they are intrinsic and contained within a cell. But when you juice it, then you break down the cell and release the sugar and it becomes a free sugar/ extrinsic)
-Should only eat 30g per day
What is starch. How much energy should it provide but how much do we get
- A polysaccharide made of glucose monomers joined in alpha 1,4 linkages. [Amylose + amylopectin]
- potatoes, cereals, bread, pasta
- It is about 24% but should be at least 30%
Protein functions, requirement, sources, calculating requirement
- Growth repair, energy, maintenance of tissue, hormones and enzymes.
- Sources from meat, fish, dairy products, veg, quoin, nuts, soya
- Amount required is the amount needed to be in nitrogen balance (nitrogen input=output)
- About 12% of total energy
- About 0.75-1.5 g per kg of body weight
The 3 types of protein deficiencies an the disease and symptoms they cause
- Protein-energy: Marasmus - severe muscle wasting, decreased insulin, oedema
- Protein: Kwashiokor- energy maintained but protein is deficient causing high insulin, oedema
- Malnourished: NOMA - ulcerating stomatitis of upper gum, ulceration of cheeks
What is fibre. Sources. Functions. Rough intake per day
- Found in whole grains, fruit, veg, legumes, nuts, and it cannot be broken down by the body
- Increases faecal mass
- Lowers risk of cardio-metabolic disease, colo-rectal cancer, lowers BP and cholesterol
- 30 g per day
What is a vitamin. Differences between water soluble and fat soluble vitamins and give examples
- Vitamins are organic substances required in small amounts. Absence leads to a deficiency disease
- Water-soluble= not stored well, needed regularly, generally not toxic in excess. B and C
- Fat soluble= stored, not absorbed or excreted easily. ADEK
Thiamin (B1): sources, function, deficiency, oral relevance, requirements
*All B vitamins act as co-enzymes in metabolic pathways
- whole grain, pork, poultry, fish , veg, dairy
- 0.5mg
- glucose metabolism
-Deficiency= cardiovascular problems, memory loss,
Riboflavin (B2) sources, function, deficiency, oral relevance, requirements
- milk, protein-bound,
- aids in release of energy from proteins
- FAD, redox reactions, blood production, body growth
- deficiency rare, except in alcoholics. Causes angular stomatitis
- not toxic in excess
Niacin: sources, function, deficiency, oral relevance, requirements
- cereals, wheat, rice
- NAD and NADP redox reactions
- lowers plasma lipid
- deficiency= pellagra (dermatitis, diarrhoea, dementia)
Pyridoxine (B6): sources, function, deficiency, oral relevance, requirements
- Beef liver.Tuna.Salmon.Fortified cereals.Chickpeas.Poultry.
- amino acid metabolism
- synthesis of serotonin, NA, haem
- treats seizures
- used in Down’s syndrome and autism
- deficiency usually caused by antagonists for diseases that increase requirements - tuberculosis, rheumatoid arthritis etc. So given supplements
- toxicity causes peripheral neuropathy
Why alcoholics may suffer vitamin deficiencies
- They may have adequate energy intake but this may be regarded as empty calories from alcohol, with inadequate levels of vitamins and nutrients.
- GI tract malfunctions
- Cirrhotic liver which affects storage, transport and metabolism of vitamins
- Stroage and transport of fat-soluble vitamins may be impaired.
Folate: sources, function, deficiency causes and signs, requirements
- mainly in green veg, liver and whole grains
- 50ug
- carrier of 1-C fragments in amino acid synthesis (methionine) and DNA synthesis (deoxyuridylic acid to deoxythymidylate) for example
- deficiency due to poor diet, low levels of greens, alcoholism. Causes tiredness, blurred vision, pins and needles, confusion (same as B12) Causes neural tube defects
Vitamin B12: sources, function, deficiency causes and signs, requirements, absorbance
- a carrier of methyl groups in metabolism.
- a cofactor in DNA synthesis (homocysteine to methionine). Needed in fatty acid metabolism, and amino acid metabolism (methyl-malonyl CoA to succinylcholine-CoA).
- only present in animal tissues
- it binds to intrinsic factor secreted by gastric cells to allow for absorption and transport. Lack of intrinsic factor most common cause of pernicious anaemia.
- absorbed in small intestine
- 1 ug required daily
- Vegan diets provide no B12 so risk of deficiency. Signs include tiredness, anorexia, megaloblastosis, anaemia. Neurolgical changes such as numbness, moodiness due to lesions and inadequate myelin synthesis.
Pantothenic acid: sources, function, deficiency
- Small amounts in a wide range of foods
- component of co-enzyme A that transfers carbon chains (eg. in fatty acid oxidation)
- Deficiency rare
Biotin: sources, function, deficiency, requirements
- peanuts, chocolate, egg yolk. Made in intestinal bacterial synthesis
- prosthetic group for carboxylations. (pyruvate carboxylases, acetyl CoA to malonyl CoA)
- deficiency rare in normal diet. Except diets with raw eggs and wine. Also, long term antibiotic therapy as it sterilises the GI tract