Theme C Flashcards
What are the analytical methods for collecting population research?
Trials - RCTS
What are the descriptive methods for collecting population research?
Survey
Case report
Case series
What are the observational methods for collecting population research?
Cohort
Case control
Describe a case control study
Observational
Begin with cases (people with the disease or outcome) and the controls (those without the disease or outcome)
Look into the past to look for risk factors or absence of risk factors
Describe cohort studies
Observational
Start with people who do not have the disease
Classify whether they are in the risk factor group or no risk factor
After a period of time look to see who has the disease / outcome
What are the problems associated with observational studies?
Confounding
Bias
What are some of the problems with measuring diet?
Random error
Homogeneity of exposure
Bias
Confounding
How can you measure diet?
Food disappearance data (national level)
Household surveys
Individual surveys
(24 hour recall, food frequency, diet diary, bio markers)
Pros and cons of diet diaries
Records diet as eaten
More flexible
Better estimate of energy and absolute intake
Requires effort to complete
Expensive to code
Alters diet while diary completed
What is internal validity?
Extent to which a causal conclusion based on the study is warranted.
Extent to which a study minimises systematic error
What is external validity?
Extent to which the results of the study can be generalised to other situations and other people
What can limit the generality of study findings?
- Situational specifics e.g. time, location, researcher, extent of measurement, treatment administration
- Pretest - if cause effect relationship are only found in pretest
- Post test - if cause effect relationship are only found in post test
- Reactivity - if effects only ocurred as an effect of studying the situation
- Rosenthal effects - inferences about cause-consequence relationships may not be generalisable to other researchers
Why do we need evidence based medicine?
Increasing medical knowledge Limited time to read Inadequacy of traditional sources Disparity between diagnostic skills/ clinical judgement Can improve medical practice
What are the four components for an evidence based decision?
Evidence from research
Clinical expertise
Patient preference
Available resources
What are the different types of research study?
Cohort Case control Randomised control trias Qualitative approaches Diagnostic and screening studies Systematic reviews
What is a cohort study appropriate for?
Prognosis
Cause
What is a case control study appropriate for?
Cause
What is a RCT appropriate for?
treatment interventions
benefits and harm
cost effectiveness
What is a qualitative study appropriate for?
Patients and/or practitioners perspective
What is the process for evidence based medicine?
- Convert the need for information into an answerable questions
- Identifying best evidence to answer that question
- Understanding it
- Critically appraising evidence for validity, impact and applicability
- Integrating critical appraisal with clinical expertise, patient circumstances and service constraints
- Evaluating effectiveness of steps 1-5
What is a background question?
General knowledge about a disorder
Who/what/where/when…. disorder
What is a foreground question?
Specific knowledge about managing patients with a disorder
Patient/problem
Intervention
Comparison intervention
Clinical outcomes
What is the control of communicable diseases based on?
Surveillance
Preventative measures
Outbreak investigation
Appropriate control measures
What are the host factors that influence infection?
Age Gender Alcoholism Drug abuse Co-existing diseases Port of entry Immuno-state Nutrition Genetic make up Cell receptors