Theme 4: The Nervous System (L8-13)

Question 1

What types of receptors stimulate serotonin?

Answer 1

G-protein coupled receptors
Ligand gated ion channels

Question 2

What NT is an ester?

Answer 2

Acetylcholine

Question 3

What type of NT are monoamines?

Answer 3

Serotonin
Norepinephrine
Dopamine

Question 4

What NTs are amino acids?

Answer 4

Glutamate
GABA

Question 5

What NTs are peptides?

Answer 5

Substance P
Enkephalins
B-endorphins

Question 6

What are the different ionotropic glutamate receptors?

Answer 6

AMPA/kainate
NMDA

Question 7

What re the ionotropic GABA receptors?

Answer 7

GABA-A

Question 8

What areas does acetylcholine work in?

Answer 8

CNS
Autonomic nervous system
Neuromuscular junction

Question 9

What are the properties of norepinephrine?

Answer 9

CNS-neuromodulator - increase arousal and alertness
ANS - postganglionic transmitter SNS

Question 10

What is the function of histamine?

Answer 10

Promotes wakefulness
Neuromodulator

Question 11

What are the properties of dopamine?

Answer 11

CNA - reward pathways, DA projections on striatum in PD
Increase Na+ excretion in kidney, reduces motility in GI, reduces activity of lymphocytes

Question 12

What are the different functions of serotonin?

Answer 12

Gut - created in GI (enterochromaffin cells), transmitter in enteric nervous system
Blood - in vessels, vasoconstriction - positive inotropic action on heart, platelets store 5HT and release to promote vasoconstriction and clotting
CNS - reward and mood