theme 2- CB10, Cell communication, range of cell signalling molecules, their receptors and functions Flashcards
Why do cells communicate? = is just extra info to make sense of point, recall brackets and e.g. tho
- To develop( so defining position, function, fate, growth) = cells in the embryo exchange chemical signals they receive from other cells to decide what a cell will specialise into, its position, and whether it survives, divides or dies
- To function (as a community of cells) E.g. the physiological function of a tissue is co-ordinated via signals from other cells, e.g. biofilms, tissues
- To sense and respond to the environment (nutrients, infections, light, blood glucose levels etc.)
The means by which cells communicate is called__________(transmission and interpretation of complex signals)
signalling
Define signalling
transmission and interpretation of complex signals by cells
What happens after a signal molecule from signalling cell reaches target cell?
0) signal reception by target cell (intercation with receptor)
1) Signal transduction (convert extracellular signal into intracellular signal)
2) molecular change occurs (e.g. gene transcirptio, protein function)
3) Cell behaviour alters
What are the types of cell signals?
- hormones
- local mediators (target near by cells)
- neurotransmittors
- contact-dependent signal molecules (communication at cell membranes requiring cells to be right beside each other)
For the following chemicals give the name of a signal molecule:
For the following chemicals give the name of a signal molecule:
- Nucleotides eg
- Steroids eg
- Dissolved Gases eg
- Fatty acids derivates eg
- Nucleotides eg cAMP
- Steroids eg estrogen, testosterone, cortisol (stress hormone)
- Dissolved Gases eg Nitric oxide (NO)
- Fatty acids derivates eg the omega-6 fatty acid, arachidonic acid, is the building block for the eicosenoids — prostaglandins, thromboxanes, and leukotrienes (signalling molecules)
Describe the following for the endocrine system:
1) Range, +explanation
2) period of time it effect lasts for
3) speed of responce
1) whole body, as acts systematically for homones are tranported in the blood stream
2) long-lasting effects
3) slow
A) Describe the pathways of the following chemical cell signals in the endocrine signals to receptors? & B)state their effects
1) Amino acid derviatives
2) peptide hormones
3) steroid hormones
1&2) bind to extracullular receptors on plasma membrane (as can’t diffuse across plasma membrane),
B) regulate metabolism, developement, reproduction
3) A) bind intracellular receptors
B) regulate metabolism
What are the 4 (+1) different ways animal signal?
1) Endocrine signalling
2) Paracrine signalling
(+1)) autocrine signallingwhen cells respond to the local mediators they themselves produce)
3) Neuronal signaling
4) Contact dependent signalling
Describe:
a) the range, b) speed, c) selectivity, d) length of effects
1) Endocrine signalling
2) Paracrine signalling
3) Neuronal signaling
4) Contact dependent signalling
a) the range, b) speed, c) selectivity, d) length of effects
1) Endocrine signalling= a) whole body systemic, hormones via blood. b) slow, c) none.d) longterm
2) Paracrine signalling= a)low ECF, b) slow, c) medum, d) longterm
3) Neuronal signaling= a) large- nervousystem, b) fast, c) very, d) short term,
4) Contact dependent signalling= a) small (adjacent cells), b) slow ( required transciption), c) very, d)long term
What is the name of the signal molecule type in endocrine signalling?
hormones
What is the name of the signal molecule type in paracrine signalling?
local mediators like cyotkines and growth factors produced by some immune system cells
What is the name of the signal molecule type in neronal signalling?
neurotransmittors
What is the name of the hroup signal molecule type in contact-dependent signalling?what are these either?
Contact-denpendent signal molecules, these are either membrane or matrix bound molecules