The Wills Eye Manual: Differential Diagnosis of Ocular Symptoms (Chapter 1) Flashcards
Burning? (4 More, 6 Less)
More:
- Blepharitis,
- Meibomitis,
- DES
- Conjunctivitis
Less:
- Corneal defects
- Inflamed pterygium or pinguecula
- Episcleritis
- SLK
- Ocular toxicity (med, makeup, contact lens solution)
- Contact lens-related problems
Define Transient Visual Loss?
Vision returns to normal within 24 hours, usually within 1 hour
More common causes of transient visual loss lasting: Few seconds? Few minutes? Ten to 60 minutes?
Few seconds: Papilledema (usually bilateral)
Few minutes: Amaurosis fugax
Ten to 60 minutes: Migraine (with or without HA)
Any of these may causes varying lengths of transient visual loss.
Less common causes of transient visual loss? (9)
- Impending CRAO
- Ischemic optic neuropathy
- Ocular ischemic syndrome (carotid occlusive disease)
- Glaucoma
- Sudden change in BP (i.e. orthostatic hypotension)
- CNS lesion
- Optic disc drusen
- AION (giant cell arteritis)
- Orbital lesion (vision loss may be associated with EOM)
More common causes of sudden, painless visual loss lasting >24 hours? (7)
- RAO
- RVO
- Ischemic optic neuropathy
- Vitreous hemorrhage
- Retinal detachment
- Optic neuritis (pain with EOM in >50% of cases)
- Sudden discovery of preexisting unilateral visual loss
Less common causes of sudden, painless visual loss lasting >24 hours? (3)
- CNS disease (stroke, tumor, etc)
- Methanol poisoning
- Ophthalmic artery occlusion (may also have EOM deficit and ptosis)
More common causes of gradual, painless visual loss over weeks to months/years? (7 )
- Cataract
- Refractive error
- Open-angle glaucoma
- Chronic angle-closure glaucoma
- Chronic retinal disease (e.g, ARMD, diabetic retinopathy)
Less common causes of gradual, painless visual loss over weeks to months/years? (2)
- Chronic corneal disease (e.g., corneal dystrophy)
- Optic neuropathy/atrophy (e.g., CNS tumor)
Painful loss of vision? (5)
- Acute angle-closure glaucoma
- Optic neuritis (pain may only be with EOM)
- Uveitis
- Endophthalmitis
- Corneal hydrops (keratoconus)
Posttraumatic visual loss? (12)
- Eyelid swelling
- Corneal irregularity
- Hyphema
- Ruptured globe
- Traumatic cataract
- Lens dislocation
- Commotio retinae
- Retinal detachment
- Retinal or vitreous hemorrhage
- Traumatic optic neuropathy
- Cranial neuropathies
- CNS injury
More common causes of distortion of vision? (7)
- Refractive error
- Acquired myopia
- Acquired astigmatism
- Macular disease
- Corneal irregularities
- Intoxication (e.g. methanol, ethanol, hallucinogens)
- Pharmacologic (e.g. scopolamine patch)
Causes of acquired myopia? (5)
- Cataract
- Diabetes (edema of lens)
- Ciliary spasm
- Medications
- Retinal detachment surgery
Causes of acquired astigmatism? (4)
- Anterior segment surgery
- Chalazion
- Orbital fracture
- Corneal edema
Less common causes of distortion of vision? (7)
- Keratoconus
- Topical eye drops (e.g. mitotics, cycloplegics)
- Retinal detachment
- Migraines
- Hypotony
- CNS abnormalities (including papilledema)
- Nonphysiologic
More common causes of monocular diplopia? (5)
- Refractive error
- Incorrect spectacle alignment
- Corneal opacities or irregularities
- Cataract
- Iris defects
Less common causes of monocular diplopia? (5)
- Dislocated natural lens or lens implants
- Macular disease
- Retinal detachment
- CNS causes (very rare)
- Nonphysiologic
Typically intermittent causes of binocular diplopia? (2)
- Myasthenia gravis
- Intermittent decompensation of an existing phoria
Typically constant causes of binocular diplopia? (9)
- Isolated sixth, third, or forth nerve palsy
- Orbital disease (Thyroid eye disease, Idiopathic inflammation, Orbital tumor)
- Cavernous sinus/superior orbital fissure syndrome
- Status-post ocular surgery
- Status-post trauma (Orbital wall fracture, orbital edema)
- Internuclear ophthalmoplegia
- Vertebrobasilar artery insufficiency
- Other CNS lesions
- Spectacle problem
Eyelash loss? (9)
- Trauma
- Burn
- Thyroid disease
- Vogt-Koyanagi-Harada syndrome
- Eyelid infection or inflammation
- Radiation
- Chronic skin disease (e.g. alopecia areata)
- Cutaneous neoplasm
- Trichotillomania
Eyelid crusting? (3 More, 3 Less)
More:
- Blepharitis
- Meibomitis
- Conjunctivitis
Less:
- Canaliculitis
- Nasolacrimal duct obstruction
- Dacryocystitis
More common causes of eyelid swelling associated with inflammation (usually erythematous)?
- Hordeolum
- Blepharitis
- Meibomitis
- Preseptal or orbital cellulitis
- Trauma
- Contact dermatitis
- Herpes simplex or zoster dermatitis
Less common causes of eyelid swelling associated with inflammation (usually erythematous)? (9)
- Ectropion
- Corneal abnormalities
- Urticaria or angioedema
- Blepharochalasis
- Insect bite
- Dacryoadenitis
- Erysipelas
- Eyelid or lacrimal gland mass
- Autoimmune disease
Eyelid Twitching? (10)
- Orbicularis myokymia (fatigue, caffeine, meds, stress)
- Corneal or conjunctival irritation
- Dry eye
- Blepharospasm (bilateral)
- Hemifacial spasm
- Albinism (photosensitivity)
- Serum electrolyte abnormality
- Tourettes
- Tic douloureux
- Anemia (rarely)
Unable to close eyelids? (6)
- Severe proptosis
- Severe chemosis
- Eyelid scaring
- Eyelid retractor muscle scarring
- Seventh cranial nerve palsy
- Status-post facial cosmetic or reconstructive surgery
Eye “Jumping” (Oscillopsia)? (7)
- Acquired nystagmus
- Internuclear ophthalmoplegia
- Myasthenia gravis
- Vestibular function loss
- Opsoclonus/ocular flutter
- Superior oblique myokymia
- Various CNS disorders
More common causes of flashes of light? (5)
- Retinal break or detachment
- Posterior vitreous detachment
- Migraine
- Rapid eye movement
- Oculodigital stimulation
Less common causes of flashes of light? (6)
- CNS disorders (particular occipital lobe)
- Vestibulobasilar artery insufficiency
- Optic neuropathies
- Retinitis
- Entoptic phenomena
- Hallucinations
Foreign body sensation? (9)
- DES
- Blepharitis
- Conjunctivitis
- Trichiasis
- Corneal abnormality
- Contact lens-related problem
- Episcleritis
- Pterygium
- Pinguecula
Glare (8)
- Cataract
- Pseudophakia
- Posterior capsular opacity
- Corneal irregularity or opacity
- Altered pupillary structure or response
- Status-post refractive surgery
- Posterior vitreous detachment
- Pharmacologic (e.g. atropine)
Hallucinations (Formed images)? (11)
- Posterior vitreous detachments (white lighting streaks of Moore)
- Retinal detachment
- Optic neuropathies
- Blind eyes
- Bilateral eye patching
- Charles Bonnet Syndrome
- Psychosis
- Parietotemporal area lesions
- Other CNS disorders
- Intoxications
- Medications
Halos Around Lights? (12)
- Cataracts,
- Pseudophakia
- Posterior capsular opacity
- Acute angle-closure glaucoma due to corneal edema
- Corneal edema of any cause
- Corneal dystrophies
- Status-post refractive surgery
- Corneal haziness
- Discharge
- Pigment dispersion syndrome
- Vitreous opacities
- Drugs (e.g., digitalis, chloroquine)
Itchy Eyes? (
- Conjunctivitis
- Blepharitis
- Dry-eye Syndrome
- Topical drug allergy
- Contact dermatitis
- Giant Papillary Conjunctivitis
- Contact lens-related problem
Common causes light sensitivity (Photophobia) with abnormal eye exam? (2 More, Less)
More:
- Corneal abnormality (e.e., abrasion or edema)
- Anterior uveritis
Less:
- Conjunctivitis (mild photophobia)
- Posterior uveitis
- Scleritis
- Albinism
- Total color blindness
- Aniridia
- Mydriasis
- Congenital glaucoma
Night Blindness (6 More, 3 Less)?
More:
- Refractive error (especially undercorrected myopia)
- Advanced glaucoma or optic atrophy
- Small pupil
- Retinitis pigmentosa
- Congenital stationary night blindness
- Status-post panretinal photocoagulation
Less:
- Vitamin A deficiency
- Gyrate atrophy
- Choroideremia
Mild to moderate ocular pain? (13)
- Dry-eye syndrome
- Blepharitis
- Infectious conjunctivitis
- Episcleritis
- Inflamed pinguecula or pterygium
- Foreign body (corneal or conjunctival)
- Corneal disorder (e.g., superficial punctate keratopathy)
- Superior limbic keratoconjunctivitis
- Ocular medication toxicity
- Contact lens-related problems
- Postoperative
- Ocular ischemic syndrome
- Eye strain from uncorrected refractive error
Moderate to severe pain? (6)
- Corneal disorder
- Trauma
- Anterior uveitis
- Scleritis
- Endophthalmitis
- Acute angle-closure glaucoma
Periorbital pain? (7)
- Trauma
- Hordeolum
- Preseptal cellulitis
- Dacryocystitis
- Dermatitis (e.g. contact, herpes zoster, herpes simplex)
- Referred pain (e.g., dental, sinus)
- Tic douloureux
Orbital pain? (9)
- Sinusitis
- Trauma
- Orbital cellulitis
- Idiopathic orbital inflammatory syndrome
- Orbital tumor or mass
- Optic neuritis
- Acute dacryoadenitis
- Migraine or cluster headache
- Diabetic cranial nerve palsy
Asthenopia? (5)
- Uncorrected refractive error
- Phoria or tropia
- Convergece insufficiency
- Accommodative spasm
- Pharmacologic (miotics)
Adnexal causes of red eye? (10)
- Trichiasis
- Distichiasis
- Floppy eyelid syndrome
- Entropion or ectropion
- Lagophthalmos
- Blepharitis
- Meibomitis
- Acne rosacea
- Dacryocystitis
- Canaliculitis
Conjunctival causes of red eye? (11)
- Ophthalmia neonatorum (infants)
- Conjunctivitis
- Subconjunctival hemorrhage
- Inflamed pinguecula
- Superior limbic keratoconjunctivitis
- Conjunctival foreign body
- Symblepharon
- Ocular cicatricial pemphigoid
- Stevens-Johnson Syndrome
- Toxic epidermal necrolysis
- Conjunctival neoplasm
Corneal causes? (8)
- Infectious or inflammatory keratitis
- Contact lens-related problems
- Corneal foreign body
- Recurrent corneal erosion
- Pterygium
- Neurotrophic keratopathy
- Medicamentosa
- Ultraviolet or chemical burns
Other causes of red eye?
- Trauma
- Postoperative
- Dry-eye syndrome
- Endophthalmitis
- Anterior uveitis
- Episcleritis
- Scleritis
- Pharmacologic
- Angle-closure glaucoma
- Carotid-cavernous fistula (corkscrew conjunctival vessels)
- Cluster headaches
Transient “Spots” in front of the eyes? (1)
-Migraines
Permanent or longstanding “Spots” in front of the eyes? (4 More, 4 Less)
More:
- Posterior vitreous detachment
- Intermediate or posterior uveitis
- Vitreous hemorrhage
- Vitreous condensations/debris
Less:
- Microhyphema
- Hyphema
- Retinal break or detachment
- Corneal opacity or foreign body
Tearing in adults with pain present?
- Corneal abnormality (e.g., abrasion, foreign body or rust ring, recurrent erosion, edema)
- Anterior uveitis
- Eyelash or eyelid disorder
- Conjunctival foreign body
- Dacryocystitis
- Dacryoadenitis
- Canaliculitis
- Trauma
Tearing with minimal or no pain?
- Dry-eye syndrome
- Blepharitis
- Nasolacrimal duct obstruction
- Punctal occlusion
- Lacrimal sac mass
- Ectropion
- Conjunctivitis
- Emotional states
- Crocodile tears (congenital or seventh nerve palsy)
Tearing in children?
- Nasolacrimal duct obstruction
- Congenital glaucoma
- Corneal or conjunctival foreign body