The use of linked markers in genetic disease

Question 1

What are the principles of genetic linkage?

Answer 1

• The tendency for alleles at neighbouring loci to segregate together at meiosis is the phenomenon of genetic linkage
• therefore to be linked, two loci must be very close together
• Alleles at linked loci = haplotype - mark chromosomal segments which can be tracked through pedigrees and poplns
• Cross-overs are more likely to occur in loci that are further away

Question 2

How do we calculate the recombination frequency?

Answer 2

• RF - number of recombinants / number of recombinants + number of non-recombinants
• I