The Sympathetic Nervous System and the Renin Angiotensin System Flashcards
Where the baroreceptors located?
Carotid sinus + aortic arch
What happens if there is an increase in baroreceptor firing?
This decrease the discharge of the sympathetic nervous system leading to a decrease in blood pressure and heart rate.
What neurotransmitter do all parasympathetic neurones release?
Acetylcholine
What is the most common neurotransmitter released at the effector end of a sympathetic neurone and what are some exceptions?
Noradrenaline
Exceptions: the adrenal medulla acts as a specialised post-ganglionic neurone as the chromaffin cells produce mainly adrenaline (80%) and noradrenaline. Sympathetic neurons to sweat glands release acetylcholine.
What are the two catecholamines?
Noradrenaline
Adrenaline
Describe the two methods of uptake of catecholamines from the synaptic cleft and state the two enzymes involved in their breakdown.
They are either taken up into the presynaptic neuron that released them or into extraneuronal tissue.
Enzymes = Monoamine Oxidase (MAO) and Catechol-O Methyltransferase (COMT)
How are the adrenorecepors divided?
Alpha - excitatory on smooth muscle cells
Beta - relaxant on smooth muscle cells + stimulatory on heart
Where are beta 1 receptors located?
Heart Muscle
GI tract
Where are beta 2 receptors located?
Bronchi
Vasculature
Uterine Smooth Muscle
Where are alpha 1 receptors located and what is their main function?
Post-synaptic membrane - they mediate VASOCONSTRICTION
Where are alpha 2 receptors located and what is their function?
They are located on the presynaptic membrane and are involved in negative feedback.
Some are post-synaptic on smooth muscle cells and cause VASOCONSTRICTION (like alpha 1 cells)
Describe the structure of the adrenoreceptors.
Alpha 1 = Gq protein linked (PLC)
Alpha 2 + Beta 1 + Beta 2 = Adenylate Cyclase (G alpha)
How do the effects of cAMP on smooth muscle, platelets and cardiomyocytes vary?
Increasing cAMP is:
INHIBITORY = smooth muscle + platelets
STIMULATORY = cardiomyocytes (unique)
Which adrenoreceptors do noradrenaline and adrenaline act on?
Noradrenaline = a1 + a2 + b1 Adrenaline = ALL the adrenoreceptors
State two synthetic compounds that can act on the adrenoreceptors and which adrenoreceptors do they act on?
Isoprenaline = b1 + b2 (pure beta agonist) Phenylephrine = a1