The Skin in Systemic Disease Flashcards
What is the condition and what systemic illness is it associated with?
Ecthyma (Ecthyma is a skin infection characterised by crusted sores beneath which ulcers form.)
Diabetes Meilltus
What is the condition and what systemic illness is it associated with?
Pretibial Myxoedema
Hyperthyroidism - Graves disease
(can also occur with hypothyroidism)
What is the condition and what systemic illness is it associated with?
Diabetic Dermopathy
- used to describe the small, round, brown atrophic skin lesions that occur on the shins of patients with diabetes. T
What is the condition and what systemic illness is it associated with?
Necrobiosis Lipodica (Necrobiosis lipoidica diabeticorum: A dull red raised area on the skin that evolves into a shiny scar with a violet border, most often on the shin)
DM
What is the condition and what systemic illness is it associated with?
Tinea pedis
DM
What is the condition and what systemic illness is it associated with?
Necrobiosis Lipodica Diabeticorum
DM
What is the condition and what systemic illness is it associated with?
Thyroid Acropathy (Thyroid acropachy is a rare condition presenting in patients who are or who have been thyrotoxic. Acropachy means thickening of the extremities and it is manifested by a triad of signs: digital clubbing, soft tissue swelling of the hands and feet, and periosteal new bone formatio)
What is the condition and what systemic illness is it associated with?
Neuropathic Ulcer (Neuropathic ulcers form as a result of peripheral neuropathy, typically in diabetic patients. Local paresthesias, or lack of sensation, over pressure points on the foot leads to extended microtrauma, breakdown of overlying tissue, and eventual ulceration)
What conditions are associated with thyroid?
Xerosis (dry skin)
Pruritis
Diffuse hair loss
Periorbital and facial oedema, pretibial myxoedema
Thyroid acropathy
What skin changes do you get addisons and cushings?
Addisons: hyperpigmentation
Cushings: Striae
What is the condition and what systemic illness is it associated with?
Eruptive Xanthoma
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Tuberous Xanthoma (Xanthoma tuberosum (also known as tuberous xanthoma) is characterized by xanthomas located over the joints)
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Tendinous Xanthoma (Xanthoma tendinosum (also tendon xanthoma or tendinous xanthoma[5]) is clinically characterized by papules and nodules found in the tendons of the hands, feet, and hee)
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Xanthelasma
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Dermatitis Herpetiformis (chronic, intensely itchy, blistering skin manifestation of gluten-sensitive enteropathy, commonly known as celiac disease..- most commonly effecting elbows, knees and buttocks)
What is the skin condition and the system it is related to?
Hereditary Haemorrhagic Telangiectasia (Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Weber–Rendu disease and Osler–Weber–Rendu syndrome, is a rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in the skin, mucous membranes, and often in organs such as the lungs, liver, and brain.)
Gatroenterology
What group of conditions are these?
Vasculitis
Red spots usually on the arms or legs
Describe the rash and name the condition?
D: localised to the face in photosensitive areas
C: butterfly configuration
M: erythematous macules
Systemic Lupus Erythematosus
What is the diagnosis and what are the causes?
Erythema Nodosum
IBD
Sarcoidosis
Inf: strep. TB
Drugs: Sulphonamides, OCP
Idiopathic
What is the following condition and what illnesses is associated with?
Pyoderma gangrenosum: note purpley tinge to the border
IBD
Myeloid diseases
Rheumatoid Artiritis
Diabetes
A patient comes in with proximal muscle weakness, teangiectasia in the nail folds and the following skin rashes/lesions, what is the diagnosis and what should be investigated for?
Dermatomyositis
25% of those will have an underlying malignancy,
- Ovarian
- Lung
- Colorectal
- Pancreatic
- Hodgkin’s lymphoma
Note: rash on the upper eyelid is known as a heliotrope rash
Erythematous papules on the hand are known as Gottron;s papules
What is the follwoing condition, which regions does it commonly occur and what diseases is it related to?
Acanthosis Nigricans
Armpit, groin and neck
Gastric Adenocarcinoma
Diabetes
Obesity
The following condition is caused by a drug reaction, what is the condition, and which medications is it associated with?
Toxic Erythema
Antibiotics and sulphonamides
The following condition is caused by a drug reaction, what is the condition, and which medications is it associated with?
Uticaria
Salicylate and transiently after certain vaccines
What sort of reaction does the following image show?
A phototoxic reaction
What is the following condition and what other dematological conditions is it associated with?
Erythema Multiforme
- unknown cause
- deposition of IgM boudn complexes in the superficial microvasculature of the skin and oral mucous membrane
- usually follows an infection or drug exposure
- Associated with Steven Johnsons Syndrome and Toxic Endodermal Necrolysis
What is the following condition and where does it usually occur?
Steven Johnson Syndrome (Stevens-Johnson syndrome is a rare, serious disorder of your skin and mucous membranes. It’s usually a reaction to a medication or an infection. Often, it begins with flu-like symptoms, followed by a painful red or purplish rash that spreads and blisters.)
Mucosal sites
May be severe eye and oral involvement
Includes prodome of fever and respiratory symptoms
What is the following condition, what other symptoms will the patient have, what is the potential causative drug and what is the associated mortality?
Toxic Epidermal Necolysis
Fever, Pain, Blistering and skin loss covering >30% body surface area
Mortality about 35%
Causative drugs: NSAIDs, antibiotics, anticonvulsants
What is the following condition and what conditions is it associated with?
Acquired Ichthyosis (fish scale skin)
- dry and rough skin with scaling
- appears early adult life
- associated with internal diseases
- underactive thyroid
- kidney disease
- sarcoidosis
- HIV
- some medicationd malignancy - hodgkin lymphoma
