The Skin and Wound Healing Flashcards
Describe the basic anatomy and physiology of the skin
- it is the largest organ of the body
- it receives 1/3 of all circulating blood volume
- it makes up about 10% of total body weight
- it varies in thickness
Describe the structure of the skin
- epidermis
- -> outermost layer
- -> avascular
- -> regenerates every 4-6 weeks
- -> functions as a protective barrier preventing environmental damage and microorganism invasion
- -> thickness varies, thicker on palms of hands and soles of feet - dermis
- -> provides support and transport of nutrients to epidermis
- -> contains blood and lymphatic vessels, swear and oil glands and hair follicles
- -> it is made up of collagen, fibroblasts, elastin and other extra cellular proteins
- -> the connective tissue within the dermis is highly elastic and its strength helps maintain the skins integrity - hypodermis
- -> subcutaneous adipose fatty tissue
What are the functions of the skin?
- outer boundary for the body and helps preserve the balance within
- protection barrier against microorganisms, radiation, chemicals, mechanical impacts and pressure
- thermoregulation
- -> it is sensitive to fluctuations in temperate, perspiration, shivering and peripheral circulation - metabolism
- synthesis of vitamin D from sunlight
- secretion
- excretion
- cosmetic
- non-verbal communication
What is the definition of a wound?
- an injury to living tissue
- a discount intuit in epithelium - may also involve connective tissue
- a breakdown in protective function
What are the causes of wounds?
- contusion (bruise)
- abrasion (graze/friction)
- laceration (tear)
- incision (cut/surgical insult)
- puncture (stab)
- burn (heat, cold, chemical)
- pressure
- disease
List the common wounds that occur in perinatal women
- abrasions to nipples
- tears to genital tract
- episiotomy
- LSCS wound site
What is wound healing?
- it is a physiological process by which the body replaces and restores function to damaged tissue
- it is a cellular and biochemical process which relies on the inflammatory process
What are the objectives of wound healing?
- to control bleeding
- to prevent infection
- regeneration and repair
- to replace devitalised and missing cellular structures and tissue layers
What are the objectives of wound management?
- to heal the wound in the shortest time possible with minimal pain, discomfort and scarring
- form a flexible and fine scar with high tensile strength
Describe the phases of healing (Haemostasis)
- its aim is to have minimal blood loss and no haemotoma formation
- constriction of blood supply (vasoconstriction) in wound bed within a few seconds of injury
- platelets begin clotting
- -> they adhere to vessel walls in the wound site
- -> and change to an amorphous shape suitable for clotting
- -> they have the ability to aggregate and release chemical messengers that stimulate a clotting cascade when in contact with exposed collagen
- scab formation
- -> activated fibrin and fibronectin form a plug
- -> it also acts a structural support matrix for the wound until collagen is deposited
- -> bleeding ceases when the blood vessels thrombolise (5-10 mins).
- -> assisted by ligation, alignment optimises healing
Describe the phases of wound healing (inflammatory phase)
- occurs between 1 and 5 days
- the normal inflammatory response isolates the damaged tissue decreasing the risk of infection
- the clot and wound tissue releases pro-inflammatory cytokines and growth factors
- with the activation of clotting factors comes the release of histamine
- -> vasodilation begins - due to increased permeability of the capillary walls - plasma, proteins, leucocytes, antibodies and electrolytes exude into the surrounding tissues
- the wound appears red, swollen and hot which can be mistaken for infection
- an open blood supply cleanses the wound
- -> chemicals attract essential cells (WBC, macrophages, antibodies, enzymes, growth factors and nutrients) to reach wounded area
- -> leucocytes maintain host response by destroying bacteria and pathogens
- -> macrophages engulf and ingest invading bacteria, cleanse the wound of devitalised necrotic tissue, damaged cells and cellular debris
- -> platelet derived growth factors are released which intimate proliferative phase
- signs (erythema, heat, oedema, pain and functional disturbance)
Describe the phases of healing (proliferation and reconstructive)
- 4-24 days, growth of new tissue
- growth factors induce cellular migration, division and proliferation
- fibroblasts enlarge and migrate
- fibronectin and collagen form provisional matrix
- new collagen is laid down
- granulation tissue, formation, rebuilds viable tissue (granules, uneven, pink/red, doesn’t bleed)
- myofibroblasts grip matrix edges and contract wound
- epithelial cells proliferate over moist surface, climbing over one another to migrate, resurfacing the wound site and providing cover for new tissue
Describe the phases of wound healing (maturation/remodelling phase)
- 21 days to 1 year
- final phase once wound is closed
- collagen fibres enlarge and re orientate along lines of tension in the wound
- cellular activity is reduced
- -> redundant cells have programmed cell death and removal
- the number of blood vessels in wounded areas regress and decrease
- max tensile strength is reached from approximately 3 months although the scar will only achieve 70-80% of normal skin strength
Explain what is meant by healing by primary intention
- surgically incised (aseptic conditions)
- surgically clean margins (uncontaminated, uninfected)
- close approximation by surgical ligatures
- minimal epithelial cell mortality - small gap to bridge
- contraction plays a minor role
- healing occurs with minimal granulation tissue
- rapid in growth of wound healing cell (macrophages, fibroblasts)
- rapid skin regeneration - short healing period
- edges united by 2 weeks
- dense scar tissue by 1 month
- minimal scar tissue, neat hairline scar
Explain what is meant by healing by secondary intention
- significant sub-epithelial damage and loss
- dead space
- -> open gaping wound with large blood clot, inability to directly bridge gap between separated edges
- irregular margins (jagged edge)
- unclean, contaminated, infected
- no surgical intervention
- larger scab
- granulates filling area, from bottom to surface of wound site
- protracted healing process
- -> increased potential for infection and other complications
- the wound edges are not brought together, healing occurs by contraction and epithelialization
- large amount of scar tissue