The Nucleus and ER Flashcards

1
Q

Where does the ER start?

A

At the nuclear membrane.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the interior if the ER topologically equivalent?

A

The extracellular environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Is the interior of the nucleus topologically different to the cytosol?

A

No.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How do proteins enter the nucleus?

A

Through pores.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What kind of direction code encodes for import into the nucleus?

A

Highly positive ones.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How many membranes enclose the nucleus?

A

Two

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What kind of proteins are on the nuclear pores on the cystolic side of the nuclear membrane?

A

Fibrils.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What kind of proteins are on the nuclear pores on the nuclear side of the nuclear membrane?

A

Ring proteins.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What kind of proteins are found in the pores?

A

Nucleoporins.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What do nucleoporins recognise?

A

Positively charged amino acids.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does import of proteins into the nucleus depend on?

A

Nuclear import receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the process of a protein entering the nucleus?

A

The protein with a cargo binds to a nuclear import receptor and is recognised by the cystolic fibril. The GTP then transfers the cargo to the nucleus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Does the transfer of proteins in and out of the nucleus require energy?

A

Yes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where does co-translational translocation occur?

A

In the RER.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where does post-translational translocation occur?

A

In free ribosomes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What indicates the maturity/level of folding of a protein?

A

Its oligosaccharides.

17
Q

What happens to improperly folded proteins?

A

They are exported from the ER and degraded in the cytosol.

18
Q

Wat is responsible for protein folding?

A

ER chaperones.