The NRC Guide Flashcards
T/F At Least one of the IACUC Members must be a qualified veterinarian.
True
How often should an IACUC inspect a facility?
At least once every 6 months
Animal should be housed with a goal of maximizing ____ behavior and minimizing ____ behavior.
species-specific; stress-induced
T/F Personnel are permitted to eat or drink in the animal rooms as long as proper ppe is being used.
False
Name a special PPE requirement for people working in noisy areas.
hearing protection\ear plugs
T/F A regularly scheduled program of pest control and monitoring is required in animal facilities.
True
T/F In the Guide, the word “should” is used to express a strong recommendation for achieving a goal.
True
Why is it recommended that nonhuman primates, dogs, and cats be group housed?
Because they are social animals
How many hourly room changes does the Guide recommend in an animal room?
10 - 15
Tuberculosis and B virus infection are examples of _____ diseases that necessitate specific guidelines in the handling of nonhuman primates
zoonotic
T/F Cat cages should be 12 inches high.
False
HEPA is the acronym for _________.
High Efficiency Particulate Air
Would is be acceptable for the animal facility secretary to serve on the IACUC as the public member?
No
If social animals must be housed alone, other forms of _____ should be provided.
enrichment
If floor drains are present in animal rooms, the drainpipes should be at least ______ inches in diameter.
4
High levels of repetitive, unvarying behavior in laboratory animals are know as ________.
stereotypies
How does the *Guide *define major surgery?
Penetrates and exposes a body cavity or produces substantial impairment of physical or physiological function or involves extensive tissue dissection or transection
Name three benefits of group- or pair-housing conspecifics.
Essential for normal development in many species; companion might buffer the effects of a stressful situation; reduce behavioral abnormalities; increase opportunities for exercise; expand species-typical behavior and cognitive stimulation
For species that produce urine with high concentrations of minerals, cage surface must be treated with what type of chemical before washing?
acid solution
The physical environment immediately surrounding an animal is called its ______.
microenvironment
The IACUC must ensure compliance with the guidelines and regulations found in _______, ________, and _________.
the Guide; the Animal Welfare Regulations; the PHS Policy
A diet with non-stabilized vitamin C has a shelf life of only ______ months.
3
T/F An occupational health and safety program is not required as part of the overall animal care and use program.
False
T/F Newly received animals do not need a stabilization period, but larger animals due.
False
If animals are placed on restricted fluids for a study, what monitoring procedures are necessary?
Daily monitoring for the animal’s fluid intake, hydration status, and body condition. Depending on the species, it may be necessary to weigh the animal weekly or more frequently.
T/F The* Guide* recommends that animal technicians should be responsible for laundering the clothing they wear in the animal facility.
False
T/F Technicians working with macaques should have access to bite and scratch emergency care stations.
True
T/F The Guide recommends the used of chemicals designed to mask animal odors in animal rooms.
False
What type of animals are particularly susceptible to phototoxic retinopathy?
Albino rodents
T/F A table in the Guide shows how often bedding should be changed for rodents
False
Most animal food can be used up to about ____ months after manufacture.
6
T/F Although the Guide recommends that animal rooms have a regular light/dark cycle, it does not recommned the use of a time-controlled lighting system.
False
What is the acceptable range of relative humidity in an animal room?
30% - 70%
T/F The Guide does not address the issue of staff training.
False
According to the Guide, who is ultimately responsible for the animal care and use program
The Instiutional Offical
What is the acceptable general standard of air changes per hour in a secondary enclosure?
10 - 15
The period of restraint of any animal should be the ____ required to accomplish the research objectives.
minimum
What is the recommended practice for storing feed and bedding?
Off the floor on pallets, racks, or carts
USDA also requires that feed bags be stored away from contact with walls
T/F Toe-clipping is the preferred method of identification for small rodents.
False
Standard laboratory animal diets can be stored for 6 months after milling date except for diets that contain __________.
Vitamin C
T/F The HVAC system should be capable of adjusting dry-bulb temperature by +/- 2 oF (+/- 1 oC)
True
How often should watering devices be checked?
Daily
T/F Chemicals can be used to disinfect primary enclosures.
True
An animal housed in a stall inside of a barn. What would be considered the primary enclosure for this animal?
The stall
Assessing the health status of animals in the research program is the responsibility of the ______.
Attending Veternarian
Who should be identified as the “official responder” for the animal facility in an instiution’s disaster plan?
Colony manager or veternarian
Unless otherwise justified, methods for euthanasia of animals should be consistent with thte most up-to-date version of the ____ Guidelines for the Euthanasia of Animals.
AVMA
Is it correct to assume that the microenvironment of all the animals housed in similar cages in the same room is similar?
No
T/F According to the Guide, bedding should not be autoclaved.
False
The height of a mouse cage should be ____ inches.
at least 5
What are the recommended dimesnsions for doors within the animal facility?
at least 42 inches wide by 84 inches high
Feed should not be stored at temperatures above ____ oF.
70
T/F An aseptic surgical suite should include a special room or area for the surgeon to scrub hands and don surgical garb.
True
The height of a guinea pig cage should be ________ inches.
at least 7 inches
In animal rooms, the relative humidity should be maintained in the ________ to ________ range.
30% to 70%
T/F Cage size recommendations in the Guide are the same as those in the Animal Welfare regulations.
False
T/F Significant saving of staff time is the most usual acceptable justification for the use of restraint devices.
False
In general, the Guide recommends that animals should not be exposed to temperatures below ____ or above _____.
40oF (4.4oC); 85oF(29.4oC)
What is the difference between experimental and humane endpoints?
Experimental endpoints are when the goals and objectives of the study are reached, humane endpints are when pain or distress in the animal is prevented, terminated, or relieved.
The seperation of newly recieved animals from those already in the facility is called ____.
Quarantine
Sanitation of an animal cag involves which three tasks?
Bedding change, cleaning, and disinfecting cages
T/F The IACUC can approve space allocations that are smaller than those listed in the Guide.
True
What is the water temperature traditionally required for the final rinse in washing cages?
180oF(82.2oC)
What type of drug must be used with neuromuscular blocking agents during surgery?
General anesthetic
T/F Animal activity typically implies motor activity but also includes social interaction and cognitive activity.
True
T/F Photoperiod is a critical regulator of reproductive behavior in many species of animals.
True
What is the light level most commonly used in animal rooms?
325 lux (30 foot-candles) about 1 meter above the floor
T/f The Guide and the Animal Welfare Act Regulations use the same formula to determine minimum floor space caging requirements for dogs.
False
Which type of housing is recommended for rodents: cages with wire floors or solid-bottom cages with bedding?
solid-bottom caging with bedding
In the United States, responsibilty for reviewing and investigating animal welfare concerns lies with what groups/ and or individuals?
The IO and the IACUC
Regardless of quarantine duration, newly recieved animals should be given a period for ____, ____, and ________ stabilization.
physiologic; psychologic; nutritional
What is the general purpose for using special cages and ventilation equipment such as filter top cages, ventilated racks, and cubicles?
To minimize the spread of airborne disease agents between cages or groups of cages.
Why are cedar shavings not recommended choice for bedding?
They emit aromatic hydrocarbons that induce hepatic microsomal enzymes and cytotoxicity, reported to increase the incidence of cancer
T/F Light can affect an animal’s physiology, morphology, and behavior.
True
For what reasons are animals typically seperated by species, for example in seperate rooms?
To prevent disease transmission between species; to prevent anxiety and stress between incompatible species.
T/F Multiple major surgeries on a single animal may be permitted if scientifically justified and approved bt the IACUC.
True
T/F Restraint devices may be used as alternative methods of housing animals.
False
T/F Negative air pressure in a room is used to prevent the accidental release of infectious agents outside the room.
True
T/F Microenviromental conditions can affect the animal metabolically and physiologically and alter the animal’s susceptibility to disease.
True
Who should review the enrichment program on a regular basis to ensure it is benefical to animal wellbeing and consistent with the goals of animal use?
The IACUC, researchers, and the veternarian
What is the responsibility of the IACUC?
Oversight and evaluation of the animal care and use program, procedures, and facilities
What is the definition of laboratory animal in the Guide?
Any vertebrate animal used in research, teaching, or testing
T/F The IACUC is responsible for hiring the animal facility staff.
False
What disease should be routinely tested for in people who work near or have contact with nonhuman primates?
Tuberculosis
The organization which developed the Guide for the Care and Use of Laboratory Animals is ________.
Institute for Laboratory Animal Research (ILAR)
T/F Aeseptic technique during surgical procedure is required if non-survival surgery is being performed.
False
Room illumination should provide for nueroendocrine regulation of ________ and ________ cycles.
diurnal; circadian
T/F Rats and guinea pigs requuire the same minimum cage height according to the Guide.
True
Which word is used in the Guide to describe aspects of an animal care program that are considered imperative?
Must
How often should qualified personnel observe an animal’s health and well-being during weekends and holiday periods?
Atleast once a day
What width does the Guide recommend for animal facility corridors?
6 - 8 Feet
T/F The attending veterinarian is responsible for approving the animal use protocols.
False
Physical contact and communication among members of the same species refers to the ________ environment.
Social
____ filters should be used to remove air-borne particles from recycled air.
HEPA (High Efficancy Particulate Air)
T/F the Guide states that other animals should not be present when an animal is euthanized.
True
The physical environment of a secondary enclosure, such as a room or barn, is referred to as the ______________.
Macroenvironment
T/F The Guide does not recommend temperature ranges for specific species.
False
The illumination level in an animal room must be sufficent to allow for ____, ____, and ____.
Good housekeeping practices; Adequate inspection of the animals; Safe working conditions for personnel
Exposure to sound louder than ____ decibels can lead to increased adrenal weight and reduced fertility in rodents.
85
T/F Irradiated diets can be considered as an alternative to autoclavavle diets.
True
