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Regulatory Flash > The NRC Guide > Flashcards

The NRC Guide Flashcards

1
Q

T/F At Least one of the IACUC Members must be a qualified veterinarian.

A

True

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2
Q

How often should an IACUC inspect a facility?

A

At least once every 6 months

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3
Q

Animal should be housed with a goal of maximizing ____ behavior and minimizing ____ behavior.

A

species-specific; stress-induced

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4
Q

T/F Personnel are permitted to eat or drink in the animal rooms as long as proper ppe is being used.

A

False

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5
Q

Name a special PPE requirement for people working in noisy areas.

A

hearing protection\ear plugs

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6
Q

T/F A regularly scheduled program of pest control and monitoring is required in animal facilities.

A

True

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7
Q

T/F In the Guide, the word “should” is used to express a strong recommendation for achieving a goal.

A

True

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8
Q

Why is it recommended that nonhuman primates, dogs, and cats be group housed?

A

Because they are social animals

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9
Q

How many hourly room changes does the Guide recommend in an animal room?

A

10 - 15

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10
Q

Tuberculosis and B virus infection are examples of _____ diseases that necessitate specific guidelines in the handling of nonhuman primates

A

zoonotic

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11
Q

T/F Cat cages should be 12 inches high.

A

False

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12
Q

HEPA is the acronym for _________.

A

High Efficiency Particulate Air

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13
Q

Would is be acceptable for the animal facility secretary to serve on the IACUC as the public member?

A

No

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14
Q

If social animals must be housed alone, other forms of _____ should be provided.

A

enrichment

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15
Q

If floor drains are present in animal rooms, the drainpipes should be at least ______ inches in diameter.

A

4

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16
Q

High levels of repetitive, unvarying behavior in laboratory animals are know as ________.

A

stereotypies

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17
Q

How does the *Guide *define major surgery?

A

Penetrates and exposes a body cavity or produces substantial impairment of physical or physiological function or involves extensive tissue dissection or transection

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18
Q

Name three benefits of group- or pair-housing conspecifics.

A

Essential for normal development in many species; companion might buffer the effects of a stressful situation; reduce behavioral abnormalities; increase opportunities for exercise; expand species-typical behavior and cognitive stimulation

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19
Q

For species that produce urine with high concentrations of minerals, cage surface must be treated with what type of chemical before washing?

A

acid solution

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20
Q

The physical environment immediately surrounding an animal is called its ______.

A

microenvironment

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21
Q

The IACUC must ensure compliance with the guidelines and regulations found in _______, ________, and _________.

A

the Guide; the Animal Welfare Regulations; the PHS Policy

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22
Q

A diet with non-stabilized vitamin C has a shelf life of only ______ months.

A

3

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23
Q

T/F An occupational health and safety program is not required as part of the overall animal care and use program.

A

False

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24
Q

T/F Newly received animals do not need a stabilization period, but larger animals due.

A

False

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25
Q

If animals are placed on restricted fluids for a study, what monitoring procedures are necessary?

A

Daily monitoring for the animal’s fluid intake, hydration status, and body condition. Depending on the species, it may be necessary to weigh the animal weekly or more frequently.

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26
Q

T/F The* Guide* recommends that animal technicians should be responsible for laundering the clothing they wear in the animal facility.

A

False

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27
Q

T/F Technicians working with macaques should have access to bite and scratch emergency care stations.

A

True

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28
Q

T/F The Guide recommends the used of chemicals designed to mask animal odors in animal rooms.

A

False

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29
Q

What type of animals are particularly susceptible to phototoxic retinopathy?

A

Albino rodents

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30
Q

T/F A table in the Guide shows how often bedding should be changed for rodents

A

False

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31
Q

Most animal food can be used up to about ____ months after manufacture.

A

6

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32
Q

T/F Although the Guide recommends that animal rooms have a regular light/dark cycle, it does not recommned the use of a time-controlled lighting system.

A

False

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33
Q

What is the acceptable range of relative humidity in an animal room?

A

30% - 70%

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34
Q

T/F The Guide does not address the issue of staff training.

A

False

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35
Q

According to the Guide, who is ultimately responsible for the animal care and use program

A

The Instiutional Offical

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36
Q

What is the acceptable general standard of air changes per hour in a secondary enclosure?

A

10 - 15

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37
Q

The period of restraint of any animal should be the ____ required to accomplish the research objectives.

A

minimum

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38
Q

What is the recommended practice for storing feed and bedding?

A

Off the floor on pallets, racks, or carts

USDA also requires that feed bags be stored away from contact with walls

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39
Q

T/F Toe-clipping is the preferred method of identification for small rodents.

A

False

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40
Q

Standard laboratory animal diets can be stored for 6 months after milling date except for diets that contain __________.

A

Vitamin C

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41
Q

T/F The HVAC system should be capable of adjusting dry-bulb temperature by +/- 2 oF (+/- 1 oC)

A

True

42
Q

How often should watering devices be checked?

A

Daily

43
Q

T/F Chemicals can be used to disinfect primary enclosures.

A

True

44
Q

An animal housed in a stall inside of a barn. What would be considered the primary enclosure for this animal?

A

The stall

45
Q

Assessing the health status of animals in the research program is the responsibility of the ______.

A

Attending Veternarian

46
Q

Who should be identified as the “official responder” for the animal facility in an instiution’s disaster plan?

A

Colony manager or veternarian

47
Q

Unless otherwise justified, methods for euthanasia of animals should be consistent with thte most up-to-date version of the ____ Guidelines for the Euthanasia of Animals.

A

AVMA

48
Q

Is it correct to assume that the microenvironment of all the animals housed in similar cages in the same room is similar?

A

No

49
Q

T/F According to the Guide, bedding should not be autoclaved.

A

False

50
Q

The height of a mouse cage should be ____ inches.

A

at least 5

51
Q

What are the recommended dimesnsions for doors within the animal facility?

A

at least 42 inches wide by 84 inches high

52
Q

Feed should not be stored at temperatures above ____ oF.

A

70

53
Q

T/F An aseptic surgical suite should include a special room or area for the surgeon to scrub hands and don surgical garb.

A

True

54
Q

The height of a guinea pig cage should be ________ inches.

A

at least 7 inches

55
Q

In animal rooms, the relative humidity should be maintained in the ________ to ________ range.

A

30% to 70%

56
Q

T/F Cage size recommendations in the Guide are the same as those in the Animal Welfare regulations.

A

False

57
Q

T/F Significant saving of staff time is the most usual acceptable justification for the use of restraint devices.

A

False

58
Q

In general, the Guide recommends that animals should not be exposed to temperatures below ____ or above _____.

A

40oF (4.4oC); 85oF(29.4oC)

59
Q

What is the difference between experimental and humane endpoints?

A

Experimental endpoints are when the goals and objectives of the study are reached, humane endpints are when pain or distress in the animal is prevented, terminated, or relieved.

60
Q

The seperation of newly recieved animals from those already in the facility is called ____.

A

Quarantine

61
Q

Sanitation of an animal cag involves which three tasks?

A

Bedding change, cleaning, and disinfecting cages

62
Q

T/F The IACUC can approve space allocations that are smaller than those listed in the Guide.

A

True

63
Q

What is the water temperature traditionally required for the final rinse in washing cages?

A

180oF(82.2oC)

64
Q

What type of drug must be used with neuromuscular blocking agents during surgery?

A

General anesthetic

65
Q

T/F Animal activity typically implies motor activity but also includes social interaction and cognitive activity.

A

True

66
Q

T/F Photoperiod is a critical regulator of reproductive behavior in many species of animals.

A

True

67
Q

What is the light level most commonly used in animal rooms?

A

325 lux (30 foot-candles) about 1 meter above the floor

68
Q

T/f The Guide and the Animal Welfare Act Regulations use the same formula to determine minimum floor space caging requirements for dogs.

A

False

69
Q

Which type of housing is recommended for rodents: cages with wire floors or solid-bottom cages with bedding?

A

solid-bottom caging with bedding

70
Q

In the United States, responsibilty for reviewing and investigating animal welfare concerns lies with what groups/ and or individuals?

A

The IO and the IACUC

71
Q

Regardless of quarantine duration, newly recieved animals should be given a period for ____, ____, and ________ stabilization.

A

physiologic; psychologic; nutritional

72
Q

What is the general purpose for using special cages and ventilation equipment such as filter top cages, ventilated racks, and cubicles?

A

To minimize the spread of airborne disease agents between cages or groups of cages.

73
Q

Why are cedar shavings not recommended choice for bedding?

A

They emit aromatic hydrocarbons that induce hepatic microsomal enzymes and cytotoxicity, reported to increase the incidence of cancer

74
Q

T/F Light can affect an animal’s physiology, morphology, and behavior.

A

True

75
Q

For what reasons are animals typically seperated by species, for example in seperate rooms?

A

To prevent disease transmission between species; to prevent anxiety and stress between incompatible species.

76
Q

T/F Multiple major surgeries on a single animal may be permitted if scientifically justified and approved bt the IACUC.

A

True

77
Q

T/F Restraint devices may be used as alternative methods of housing animals.

A

False

78
Q

T/F Negative air pressure in a room is used to prevent the accidental release of infectious agents outside the room.

A

True

79
Q

T/F Microenviromental conditions can affect the animal metabolically and physiologically and alter the animal’s susceptibility to disease.

A

True

80
Q

Who should review the enrichment program on a regular basis to ensure it is benefical to animal wellbeing and consistent with the goals of animal use?

A

The IACUC, researchers, and the veternarian

81
Q

What is the responsibility of the IACUC?

A

Oversight and evaluation of the animal care and use program, procedures, and facilities

82
Q

What is the definition of laboratory animal in the Guide?

A

Any vertebrate animal used in research, teaching, or testing

83
Q

T/F The IACUC is responsible for hiring the animal facility staff.

A

False

84
Q

What disease should be routinely tested for in people who work near or have contact with nonhuman primates?

A

Tuberculosis

85
Q

The organization which developed the Guide for the Care and Use of Laboratory Animals is ________.

A

Institute for Laboratory Animal Research (ILAR)

86
Q

T/F Aeseptic technique during surgical procedure is required if non-survival surgery is being performed.

A

False

87
Q

Room illumination should provide for nueroendocrine regulation of ________ and ________ cycles.

A

diurnal; circadian

88
Q

T/F Rats and guinea pigs requuire the same minimum cage height according to the Guide.

A

True

89
Q

Which word is used in the Guide to describe aspects of an animal care program that are considered imperative?

A

Must

90
Q

How often should qualified personnel observe an animal’s health and well-being during weekends and holiday periods?

A

Atleast once a day

91
Q

What width does the Guide recommend for animal facility corridors?

A

6 - 8 Feet

92
Q

T/F The attending veterinarian is responsible for approving the animal use protocols.

A

False

93
Q

Physical contact and communication among members of the same species refers to the ________ environment.

A

Social

94
Q

____ filters should be used to remove air-borne particles from recycled air.

A

HEPA (High Efficancy Particulate Air)

95
Q

T/F the Guide states that other animals should not be present when an animal is euthanized.

A

True

96
Q

The physical environment of a secondary enclosure, such as a room or barn, is referred to as the ______________.

A

Macroenvironment

97
Q

T/F The Guide does not recommend temperature ranges for specific species.

A

False

98
Q

The illumination level in an animal room must be sufficent to allow for ____, ____, and ____.

A

Good housekeeping practices; Adequate inspection of the animals; Safe working conditions for personnel

99
Q

Exposure to sound louder than ____ decibels can lead to increased adrenal weight and reduced fertility in rodents.

A

85

100
Q

T/F Irradiated diets can be considered as an alternative to autoclavavle diets.

A

True

Regulatory Flash (7 decks)

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