The Neurology of Sleep Flashcards
What are 4 theories of sleep function?
- recuperative theories (sleep is used to maintain homeostasis and for recovery)
- circadian theories: everyone sleeps due to internal circadian rhythm and it would not be efficient for humans to be awake at night
- developmental theories: sleep changes form as we get older
- learning theories: sleep changes when we learn something and sleep deprivation causes deficits in our ability to gain long term memory
What are 2 main characteristics on the organization of sleep?
- sleep is a continuum
- EEG criteria artifically defines sleep stages (every stage of sleep occurs at once, but in different ratios)
What are sleep stages broken up into?
2 independant states (do not occur at the same time):
- REM SLEEP
- NON-REM SLEEP (NREM)
and
awake
what are the 4 divisions of nrem sleep?
N1, N2, N3
- N3 = stages 3 and 4 which is the deepest stages of sleep/slow wave sleep (SWS)
At what times and how often do nrem and REM sleep alternate?
- NREM and REM sleep alternate with each cycle lasting 90-100 mins with 4 to 6 cycles per night
What is the pattern of non-rem/sws sleep and Rem sleep
the first 2 cycles as we sleep are dominated by Slow wave sleep (SWS)
- REM sleep increases from the first to the last cycle and towards the end of the night / longest end of the night
- the first third of a normal sleep episode is dominated by SWS and the last third is dominated by REM sleep
How are EEG waves used to name sleep rhythms and define stages?
EEG rhythms are named according to the frequency of the activity going on at one second of record (# of waves/second)
what is one epoch?
during sleep, we define stages by what happens in one epoch which is 30 seconds of recording
What are the EEG frequencies of sleep rhythm?
- delta ( less than 4hz/s) –> deep sleep
- Theta (4-7 hz) –> somewhat going to deep sleep
- alpha (8-13hz) –> closed eyes resting state
- beta (greater than 14hz) –> awake
What is the most common clinical use for the sleep stages?
to identify and assess which stage people have problems by lookikng at scoring criteria and seeing what type of waves or activity was occuring during that stage of sleep
What is the EEG activity shown in awake state?
disorganized, low voltage, activity (low voltage/high freuqnecy)
what is the EEG activity shown in nREM sleep?
eeg becomes organized, in SWS we see high voltage, low frequency and slow activity
What is the EEG activity shown in REM sleep?
“awake” looking EEG except with no muscle tone and very rapid eye movements
When does dreaming occur and what kinds of dreams occur in NREM vs REM sleep?
dreaming occurs in both REM and NREM stages
- In REM, dreams are really emotional and have narrative or a plot, vivid, bizarre
- external stimuli can also be encorperated into dreams
- dreams that we remember when we wake up in the morning are due to the long REM periods we have before we wake up which allow us to remember our dreams
How does sleep change during the course of development?
- time spent in REM sleep is greatest before birth and decreases with age
- SWS appears at 4-5 months of age and increases into adulthood, and then begins to decline w age (increases in teens)
- sleep requirements diminish throughout life
What happens to our brains when we are awake?
everything in our brain is firing and excitatory
What happens to our brains during NREM sleep?
EEG becomes organized, and looks more synchronized
- everything starts to become inhibited
- reduced firing
What happens to our brains during REM sleep?
- a combination of excitatory connections in brain and inhibitory connections (mainly in the motor system and spinal cord)
What is hypocretin/Orexin?
- it is produced by cells in hypothalamus
- found to be decreased in patients with narcolepsy
- increases during third embryonic trimester and is highest at 4 months of life and then they lower and stablize as we age
Where does hypocretin get distributed in the brain and what does it do?
it gets distributed to alot of nuclei in the brain and helps stabilize their functions