The Neck, Glands of the Face, and H&N Cancers Flashcards

1
Q

What kind of cancer makes up the majority of head and neck cancers?

A

Squamous cell carcinoma

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2
Q

What are cancers of the head and neck most associated with epidemiologically?

A

Tobacco use

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3
Q

Aside from heavy smoking, what other risk factors are there for head and neck cancers?

A
Heavy alcohol consumption
Poor dentition
Socially disadvantaged groups
Poor diet (low fibre)
GORD
HPV
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4
Q

Is smoking the only way someone can use tobacco?

A

No, it can be chewed too.

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5
Q

How might a pt with a head and neck tumour present?

A
  • Persistent hoarse voice
  • Sore throat
  • Cough
  • Earache
  • Neck lump
  • Mouth lesion
  • Recurrent unilateral nosebleeds
  • Systemic features e.g. weight loss
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6
Q

How are early-stage H+N cancers usually managed?

A

Surgery or radiotherapy

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7
Q

What supportive Rx might a pt with a H+N tumour need?

A

Nutritional support
Communication support
Dentition support
Psychological support - for cancer and for possible cosmetic effect.

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8
Q

What are the salivary glands called?

A
  • Parotid gland
  • Submandibular
  • Sublingual
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9
Q

Where do the parotid glands:

a) lie?
b) open?

A

a) below the external auditory meatus

b) on the buccal membrane opposite second upper molar

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10
Q

Where do the submandibular glands:

a) lie?
b) open?

A

a) beneath and infront of angle of the jaw

b) floor of the mouth lateral to frenulum

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11
Q

Where do the sublingual glands:

a) lie?
b) open?

A

a) below the tongue

b) through several ducts on the floor of the mouth

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12
Q

How much saliva is produced in one day?

A

1-1.5 Litres

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13
Q

What are the functions of saliva?

A

Lubrication
Facilitate speech, swallowing, digestion, and mastication.
Protect oral mucosa and teeth.

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14
Q

What symptoms might a pt have relating to salivary gland pathology?

A

Swelling
Pain (gland or ear or throat)
Difficulty eating
Dry mouth

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15
Q

How can we examine the parotid gland?

A

Ask pt to clench jaw - palpate parotid gland overlying the masseter muscle.

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16
Q

Which nerve may be affected by parotid gland pathology?

A

Facial nerve

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17
Q

What other swelling can salivary gland swellings be confused with?

A

Lymph node swelling

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18
Q

What might cause parotid gland swelling?

A
  • Viral - mumps
  • Bacterial infection
  • Stone
  • Sjögren’s syndrome
  • Sarcoidosis
  • Granulomatosis
  • HIV-related lymphocytic infiltration
  • Benign or malignant tumour
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19
Q

What might cause submandibular gland swelling?

A
  • Stone in duct
  • Benign or malignant tumour
  • Sjögrens
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20
Q

What is the most common cause of salivary gland infection?

A

Mumps

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21
Q

A pt presents with a painful swelling on the side of their face. They have experienced a dry mouth and temperature along with this.

What might this be, and what other symptoms might they have?

A

Infection of parotid gland.

  • Abnormal or foul taste
  • Discharge from ducts
  • Mouth pain especially when eating
  • Difficulty talking
  • Other signs of systemic unwellness
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22
Q

How should mumps or other salivary gland infections be managed?

A

Supportively - it is self-limiting and not serious.

It is however notifiable.

Encourage salivary flow.
Abx may be necessary.
Remove stones or strictures if appropriate.

23
Q

How can salivary glands become obstructed?

A
  • Calculi or stones form from mucus, cellular debris, calcium, and magnesium phosphates.
  • Duct stenosis (post-inflamm, chronic)
  • Obstructing tumour
24
Q

How does an obstructed salivry gland present?

A

Pain and swelling in region of gland, particularly at meal times (when saliva production is stimulated)

25
Why are stones more common in the submandibular duct?
It has the thickest secretions and a smaller duct than the parotid.
26
How are salivary duct stones managed?
Many pass spontaneously -> oral analgesics and treat any infection present. Good hydration Warm compress Gland massage Surgical removal sometimes required.
27
What is sialadenosis, and with what is it associated?
Generalised gland swelling caused by acinar component hypertrophy within the gland. Systemic diseases such as Sjögren's, endocrine disorders, coeliacs, and sarcoidosis.
28
Are salivary gland tumours more commonly benign or malignant?
Benign
29
What red flags would be indicative of a malignant salivary gland tumour?
- Rapid growth of swelling - Ulceration or induration - Fixation to skin - Sensory changes - PMHx of skin cancer, H+N radiation - Sjögren's syndrome
30
How are suspected salivary gland tumours investigated?
USS
31
How are salivary gland tumours managed?
Tumours need surgical excision. | Post-op radiotherapy is needed for malignant tumours.
32
What kind of condition is Sjögren's syndrome?
Autoimmune
33
What is the pathophysiology of Sjögren's syndrome?
Autoimmune lymphocytic infiltration of exocrine glands.
34
What are the symptoms of Sjögren's syndrome?
Dry eyes Dry mouth Parotid gland swelling
35
Is Sjögren's more common in women or men?
Women, by a factor of 20!!
36
What are the risk factors for Sjögren's syndrome?
- Other autoimmune diseases | - Vitamin D deficiency
37
How is Sjögren's managed?
Symptomatic treatments - artificial tears, drink plenty of water, good dental hygiene, lubricants for other affected areas e.g. skin, vagina. DMARDs
38
What is xerostomia?
Dry mouth
39
What can cause xerostomia?
- Medication - Irradiation of head and neck region - Salivary gland disease
40
What symptoms might someone with long term xerostomia also have?
- Burning or scalded sensation - Poor oral hygiene - Intolerance to dentures
41
Who is xerostomia most common in?
The elderly and adolescents with T1DM.
42
What drugs can cause dry mouth?
- Morphine - TCA - Antihistamines - Antimuscarinics - Anti-epileptics - Antipsychotics - Beta blockers - Diuretics
43
How should drug induced xerostomia be managed?
Reduce dose or change drug if possible. | Treat symptoms with hydration and other simple measures.
44
What simple measures can aid xerostomia?
- Frequent sips of cool drinks - Sucking pieces of ice - Sugar-free sucky sweets - Sugar free chewing gum - Petrolium jelly on lips
45
What medical management can we use for xerostomia?
Artifical saliva Salivary stimulants Pilocarpine for certain indications.
46
What are the indications for pilocarpine for xerostomia?
Xerostomia cause by H+N irradiation, and Sjögren's syndrome.
47
What red flags alongside lymphadenopathy would indicate significant underlying disease?
Persistent fever Night sweats General malaise Weight loss Supraclavicular or infraclavicular nodes are always suspicious of underlying malignancy.
48
How common are palpable lymph nodes in children?
Quite - up until age 8-12 they are quite prominent.
49
What nodes can signify Hodgkins disease?
Epitrochlear (just above the elbow crease) - not H+N, sure, but interesting none-the-less.
50
Someone comes in with a neck lump. Form a list of differentials.
- Reactive lymphadenoapthy - Lymphoma - Thyroid swelling - Thyroglossal cyst - Pharyngeal pouch - Cystic hygroma - Branchial cyst - Cervical rib - Carotid aneurysm - Sebaceous cyst - Lipoma
51
How common are thyroglossal cysts?
Most common congenital anomaly of the neck - 2-4% of all neck masses.
52
How does a thyroglossal cyst present?
Fluctuant swelling in neck midline which moves upwrads when pt sticks tongue out
53
What is a thyroglossal cyst?
Cyst that forms from persistent epithelial tract from embryological descent of the thyroid down the midline of the neck.