the male Flashcards

1
Q

what is the role of the epididymis

A

sperm maturation

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2
Q

what is the role of the seminiferous tubules

A

sperm production

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3
Q

what is the purpose of the myoid cells that surround the seminiferous tubules

A

they provide a squeezing action that helps to move sperm

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4
Q

what cells are in the spaces between the seminiferous tubules

A

leydig cells

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5
Q

where does the biosynthesis of testosterone occur

A

in leading cells

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6
Q

where does the conversion of testosterone to dihydrotestosterone take place

A

in the Sertoli cells in the seminiferous tubules

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7
Q

how are steroid receptors transcription factors

A

steroid receptors have 2 binding sites one for the steroid and one for dna. blinding of the steroidal ligand acetic on the dna and alters the genes being expressed by target cells

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8
Q

where are androgen receptors expressed

A

epididymis, accessory glands, tissues where 2ndary characteristics appear

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9
Q

where is GnRH stored

A

hypothalamus

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10
Q

where is FSH and LH stored

A

anterior pituitary

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11
Q

how is GnRH released

A

pulsate release at a constant frequency

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12
Q

where is the FSH receptor located

A

on the Sertoli cell

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13
Q

where is the LH receptor located

A

on the leydig cell

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14
Q

how does FSH contribute to spermatogenesis, sperm maturation and hyoid cell contractility

A

androgen binding protein binds to T and DHT and concentrates them in the luminal fluids which stimulates the above

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15
Q

what enzyme converts T to DHT

A

5 alpha reductase

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16
Q

by what mechanism is GnRH secretion and LH and FSH inhibited

A

negative feedback with testosterone and inhibin

17
Q

where is the sperms initial ability to swim

A

in the epididymis

18
Q

what is the average vol of ejaculate

A

1.5-5ml

19
Q

what is the average sperm count

A

40-250mil/ml

20
Q

what percent of sperm are still motile 1h after ejculation

A

70%

21
Q

what percent of sperm are still motile 3h after ejac

A

60%

22
Q

ph of sperm

A

7.2-7.8

23
Q

what makes up most of the ejaculate volume

A

seminal vesicle secretion (46-80%)

24
Q

what is an erection

A

erectile tissue becoming engorged with blood

25
Q

what nervous system is ejaculation controlled by

A

sympathetic

26
Q

causes of erectile dysfunction

A

drugs e.g. beta blockers, psychogenic, neurogenic, vascular, endocrine.

27
Q

treatment of erectile dysfunction

A

prostaglandin E1 - aloprostadil

e5 - sildenafil

28
Q

risk factors for prostate cancer

A

age, ethnicity, family history

29
Q

symptoms of prostate cancer

A

urgent and frequent urination, nocturnal enuresis, difficulty starting or emptying, weak flow, interrupted, pelvic/back pain

30
Q

management of prostate cancer

A

GnRH agonists and antagonists, androgen antagonist, 5 alpha reductase inhibitors

31
Q

contraception in males

A

exogenous testosterone lowers fsh and lh