The major cytokines Flashcards
What cells produce IL-1?
macrophages, B cells, endothelium fibroblasts, astrocytes
What’s the principle target for IL1?
T cells, B cells, macrophages, endothelium tissue cells
What’s the principle effect of IL1?
lymphocyte activation, macrophage stimulation, increased leukocyte/endothelial adhesion, pyrexia, acute phase proteins
What immune cells produce IL2? What’s the principle target?
Easy - T cells and T cells (T is for Two)
What is IL2’s main function?
T cell proliferation and differentiation
What immune cells produce IL3?
T cells
WHat’s the purpose of IL3?
it’s a multilineage colony stimulating factor
What cells secrete IL4? To what target>
T cells secrete to other T cells and B cells
What’s the purpose of IL4?
It’s B cell growth factor
increases isotype selection to IgE and IgG1
What cells secrete IL5? To what target?
T cells to B cells
What’s the purpose of IL5?
B cell differentiation, IGA selection
What cells secrete IL6?
T cells and B cells
What’s the target for IL6?
B cells and hepatocytes
WHat’s the purpose of IL6?
B cell differentiation, induces acute phase proteins (from liver)
What cells secrete IL7? It’s different….
bone marrow stromal cells…to pre-B cells and T cells
What’s the purpose of IL7?
B and T cell proliferation in the bone marrow
What cells secrete IL8?
monocytes!
What’s the target for IL8?
neutrophils, basophils, T cells, keratinocytes
What’s the purpose of IL8?
cleanup in aisle 8….chemotaxis, angiogenesis, superoxide release, granule release
What cells secrete IL9?
T cells
What’ the purpos eof IL9?
enhances T cell survival, mast cell activation, synergy with erythropoitin
What cells secrete IL10?
T cells
What cells are the principle target for IL10?
Th1 cells
WHat’s the purpose of IL10?
It makes the Th1 cells inhibit cytokine synthesis to put a brake on the immune system
