The Lymphoid System and Immune Respones Flashcards
Lymph
the fluid flowing through lymphatic vessels and other structures of the lymphoid system
Lymphatic capillaries
the smallest lymphatic vessels, are found with blood capillaries in almost every tissue of the body
Lymphatic vessels
similar to veins in that smaller lymphatic vessels deliver lymph to larger lymphatic vessels as lymph flows toward the subclavian veins
Lymphatic trunks
deliver lymph into one of two lymphatic ducts
Right lymphatic duct
receives lymph from the right upper limb, right side of the thoracic cavity, and right side of head and neck and delivers lymph into right subclavian vein
Thoracic duct
begins at the cisterna chyli, which lies anterior to the second lumbar vertebra
Primary lymphoid organs
structures in which B cells and T cells become immunocompetent, meaning they become capable of an immune response. The primary lymphoid organs are the red bone marrow and thymus
Secondary lymphoid organs
where they initiate immune responses to foreign antigens
Red bone marrow
the site at which B cells form and become immunocompetent
Thymus
the site at which T cells become immunocompetent
Spleen
the largest secondary lymphoid organ in adults
Fibrous capsule
spleen surrounded by it
Splenic helium
splenic artery and vein enter and exit at a small, medial indentation, called the
White pulp
composed of splenic lymphoid nodules surrounding arteriole. The site of immune responses to and phagocytosis of other antigens within the blood
Red pulp
composed of blood-filled sinusoids and splenic cords. The red pulp is where old RBCs and platelets are filtered out of the blood and phagocytized
Lymph nodes
form clusters around lymphatic vessels
Cortex
contains lymphoid nodules
Medulla
contains medullary cords composed of reticular fibers, lymphocytes, and microphages
Mucosa-associated lymphoid tissues (MALTs)
lymphoid nodules located within the connective tissue of mucous membranes.
Tonsils
strategically positioned within the pharynx to protect the body against from inhaled and ingested pathogens
Pharyngeal tonsil
positioned posterior to the nasal cavity
Palatine tonsils
located in the posterolateral walls of the oral cavity
Lingual tonsils
located at the base of the tongue
Aggregated lymphoid nodules
located within the wall of the distal small intestine
Appendix
extends from the cecum
Nonspecific defenses
present from birth and do not discriminate among different threats to the body
Immune responses
develop with age, primarily through exposure and other disease-causing agents
First line of defense
designed to keep pathogens and disease-causing agents from entering body tissues
Second line of defense
defends the body against pathogens and disease-causing agents that have successfully entered body tissues
Interferons
protective proteins produced by virus-infected cells that cause healthy cells to produce antiviral proteins
Complement
promotes phagocytosis, inflammation, and cytolysis (rupturing) of infected cells
Natural killer cells (NK cells)
type of lymphocyte involved in nonspecific defense
Inflammation
swelling of an infected or damaged tissue that limits the spread of infection and promotes tissue repair and debris removal
Fever
an elevation of body temperature above the homeostatic value that helps to limit pathogen growth and intensify the effects of the body’s other defensive mechanisms
Third line of defense
consists of the immune responses initiated by T cells and B cells in response to foreign antigens
Cytotoxic T cells
responsible for attacking abnormal cells with foreign antigens in their plasma membranes, which is why this form of immunity is referred to as cell-mediated immunity
Helper T cells
promote the action of T cells and most B cells
Suppressor T cells
believed to play a role in limiting the activity of T cells and B cells
T memory cells
remain in the secondary lymphoid organs after exposure to a foreign antigen
Plasma cells
When activated, B cells also divide rapidly, forming a clone of similar cells. Some of the clone differentiate into plasma cells
Antibodies
produced by plasma cells that have the ability to bind to the foreign antigen
Antibody-mediated immunity
antibody deactivates the antigen and marks it for destruction
Memory B cells
same purpose as T cells